CAJ | 학술논문

目的：探讨磁共振弥散加权成像(DWI)技术在预测宫颈癌放射敏感性的应用价值。方法25例单纯放疗宫颈癌初诊患者，外照射前、20GY以及结束时分别进行1.5T磁共振常规系列及DWI扫描，测量各时间点宫颈癌原发灶ADC值，分析差异性以及与肿瘤退缩率的相关性。结果外照射前、20GY及结束时ADC值分别为(0.93±0.14)×10-3、(1.25±0.17)×10-3s及(1.55±0.13)×10-3mm2/s，两两之间差异均有统计学意义(P值<0.01)；外照射前与20GY的ADC值差值(R值)为(0.33±0.16)×10-3mm2/s。外照射前后肿瘤退缩率为(0.86±0.11)。外照射前、20GY以及结束时各ADC值与肿瘤退缩率均无相关性(P值>0.05),R值与肿瘤退缩率有正相关性(r=0.423，P=0.035)。结论宫颈癌原发灶ADC值放疗后升高；放疗后ADC值的早期变化与肿瘤退缩率具有正相关性，可作为预测宫颈癌放射敏感性的潜在性功能影像学指标。
목적：탐토자공진미산가권성상(DWI)기술재예측궁경암방사민감성적응용개치。방법25례단순방료궁경암초진환자，외조사전、20GY이급결속시분별진행1.5T자공진상규계렬급DWI소묘，측량각시간점궁경암원발조ADC치，분석차이성이급여종류퇴축솔적상관성。결과외조사전、20GY급결속시ADC치분별위(0.93±0.14)×10-3、(1.25±0.17)×10-3s급(1.55±0.13)×10-3mm2/s，량량지간차이균유통계학의의(P치<0.01)；외조사전여20GY적ADC치차치(R치)위(0.33±0.16)×10-3mm2/s。외조사전후종류퇴축솔위(0.86±0.11)。외조사전、20GY이급결속시각ADC치여종류퇴축솔균무상관성(P치>0.05),R치여종류퇴축솔유정상관성(r=0.423，P=0.035)。결론궁경암원발조ADC치방료후승고；방료후ADC치적조기변화여종류퇴축솔구유정상관성，가작위예측궁경암방사민감성적잠재성공능영상학지표。
Objective To investigate the cinical value value of diffusion-weighted magnetic resonance imaging (DWI) in predicting the radiosensitivity of cervical cancer. Methods Twenty-five women with cervical cancer received radiotherapy were included, DWI was carried out prior to radiation, and repeated after 20GY and after the readiation using MRI scanner. The apparent diffusion coefficient (ADC) was calculated, compared and correlated with final tumour retraction. Results The ADC values of prior to radiation, 20GY and t after the readiation was (0.93±0.14)×10-3, (1.25±0.17)×10-3and (1.55±0.13)×10-3mm2/s, it showed significant difference each other (P<0.01). The change of ADC between prior to radiation and 20GY therapy was (0.33±0.16)×10-3 mm2/s, final tumour retraction was (0.86±0.11)×10-3mm2/s. No correlation was found between ADC values and tumour retraction (P>0.05), while the changes in ADC showed a significant correlation with tumour retraction (r=0.423,P=0.035). Conclusion The ADC values of cervical cancer increased after radiotherapy, the early change of ADC value showed a correlation with final tumour retraction, Which has the potential to provide a surrogate biomarker of radiosensitivity in cervical cancers.