中华普通外科学文献(电子版)
中華普通外科學文獻(電子版)
중화보통외과학문헌(전자판)
CHINESE JOURNAL OF GENERAL SURGERY(ELECTRONIC VERSION)
2014年
6期
465-468
,共4页
胆道%感染%细菌谱%耐药性
膽道%感染%細菌譜%耐藥性
담도%감염%세균보%내약성
Biliary tract%Infection%Bacterial spectrum%Resistance
目的:了解胆道感染患者胆汁中主要致病菌的分布及其抗生素敏感情况。方法对福建医科大学附属龙岩第一医院2008年1月至2012年1月间收治的196例胆道感染患者进行胆汁细菌培养和抗生素敏感情况分析。结果从164例患者的胆汁中共分离171株需氧菌,总阳性率为83.67%(164/196)。171株中革兰阴性菌112株,占65.50%;革兰阳性菌59株,占34.50%。革兰阴性菌的主要致病菌包括大肠埃希菌(35.00%)、肠球菌(27.49%)、肺炎克雷白菌(10.00%)和铜绿假单胞菌(4.00%)。革兰阴性菌对碳青酶烯类药物、阿米卡星、头孢哌酮/舒巴坦仍比较敏感,耐药率分别为低于1.8%、3.5%、11.1%;革兰阳性菌对氨苄西林、阿莫西林/克拉维酸钾的耐药率分别为低于6.1%、0。耐万古霉素的肠球菌(VRE)检出率依然较低,粪肠球菌、屎肠球菌对万古霉素的耐药率分别为2.6%、0。结论头孢哌酮/舒巴坦、阿米卡星可作为治疗胆道感染的首选用药。当革兰阳性菌如肠球菌或耐甲氧西林凝固酶阴性葡萄球菌为致病菌时,应根据胆汁培养结果选用窄谱抗生素。
目的:瞭解膽道感染患者膽汁中主要緻病菌的分佈及其抗生素敏感情況。方法對福建醫科大學附屬龍巖第一醫院2008年1月至2012年1月間收治的196例膽道感染患者進行膽汁細菌培養和抗生素敏感情況分析。結果從164例患者的膽汁中共分離171株需氧菌,總暘性率為83.67%(164/196)。171株中革蘭陰性菌112株,佔65.50%;革蘭暘性菌59株,佔34.50%。革蘭陰性菌的主要緻病菌包括大腸埃希菌(35.00%)、腸毬菌(27.49%)、肺炎剋雷白菌(10.00%)和銅綠假單胞菌(4.00%)。革蘭陰性菌對碳青酶烯類藥物、阿米卡星、頭孢哌酮/舒巴坦仍比較敏感,耐藥率分彆為低于1.8%、3.5%、11.1%;革蘭暘性菌對氨芐西林、阿莫西林/剋拉維痠鉀的耐藥率分彆為低于6.1%、0。耐萬古黴素的腸毬菌(VRE)檢齣率依然較低,糞腸毬菌、屎腸毬菌對萬古黴素的耐藥率分彆為2.6%、0。結論頭孢哌酮/舒巴坦、阿米卡星可作為治療膽道感染的首選用藥。噹革蘭暘性菌如腸毬菌或耐甲氧西林凝固酶陰性葡萄毬菌為緻病菌時,應根據膽汁培養結果選用窄譜抗生素。
목적:료해담도감염환자담즙중주요치병균적분포급기항생소민감정황。방법대복건의과대학부속룡암제일의원2008년1월지2012년1월간수치적196례담도감염환자진행담즙세균배양화항생소민감정황분석。결과종164례환자적담즙중공분리171주수양균,총양성솔위83.67%(164/196)。171주중혁란음성균112주,점65.50%;혁란양성균59주,점34.50%。혁란음성균적주요치병균포괄대장애희균(35.00%)、장구균(27.49%)、폐염극뢰백균(10.00%)화동록가단포균(4.00%)。혁란음성균대탄청매희류약물、아미잡성、두포고동/서파탄잉비교민감,내약솔분별위저우1.8%、3.5%、11.1%;혁란양성균대안변서림、아막서림/극랍유산갑적내약솔분별위저우6.1%、0。내만고매소적장구균(VRE)검출솔의연교저,분장구균、시장구균대만고매소적내약솔분별위2.6%、0。결론두포고동/서파탄、아미잡성가작위치료담도감염적수선용약。당혁란양성균여장구균혹내갑양서림응고매음성포도구균위치병균시,응근거담즙배양결과선용착보항생소。
Objective To find out the main pathogenic bacteria distribution and sensitivity to antibiotics in the bile of patients with biliary tract infection. Methods The distribution and antibiotic sensitivity of 196 patients with biliary tract infection in our hospital from January 2008 to January 2012 were reviewed and analyzed. Results From 171 strains of pathogenic bacteria of 164 patients, the total positive culture rate was 83.67%(164/196). There were 112 gram-negative bacteria (65.50%) and 59 gram-positive bacteria (34.50%). The positive pathogenic bacteria include e.coli (35.00%), enterococcus (27.49%), white fungus (10.00%), klebsiella pneumoniae and pseudomonas aeruginosa (4.00%). Gram-negative bacteria were still sensitive to carbon blue enzyme alkenes medicine, amikacin, and cefoperazone/sulbactam, with drug resistance rate less than 1.8%, 3.5%and 11.1%. Gram-positive bacteria were still sensitive to ampicillin, amoxicillin/clavulanic acid potassium, with drug resistance rate less than 6.1%, 0. Conclusions Gram-negative bacteria are the main pathogenic bacteria in the bile of patients with biliary tract infection. Amikacin, cefoperazone/sulbactam may be the first choice antibiotics. Narrow-spectrum antibiotics are better for gram-positive bacteria, such as enterococcus and methicillin-resistant staphylococcus episermidis.