CAJ | 학술논문

目的：探讨甲状腺激素水平与首发和复发抑郁症之间的相关性及临床意义。方法：采用电化学发光免疫分析法，分别测定127例抑郁症患者（其中首发抑郁组66例、复发抑郁组61例）和53名正常者（正常对照组）的血清三碘甲状腺原氨酸（ T3）、甲状腺素（ T4）、游离甲状腺激素（ FT3、FT4）和促甲状腺激素（ TSH）水平；采用汉密尔顿抑郁量表（ HAMD）评估患者抑郁程度。结果：复发抑郁组血清FT3水平显著低于正常对照组（ P＝0?009），血清T3、T4、FT4、TSH水平与正常对照组差异无统计学意义；首发抑郁组血清T3、T4、FT3、FT4、TSH水平与正常对照组差异无统计学意义。相关分析显示，首发抑郁组血清T3水平与HAMD总分呈负相关（ r＝—0?250，P＝0?043）；复发抑郁组血清T3、T4、FT3、FT4、TSH与HAMD总分均无相关（r＝0?014~0?204，P均＞0?05）。结论：抑郁症首次发病与复发患者血清甲状腺激素水平存在一定变化，复发较首发抑郁者可能存在更严重的甲状腺功能减退。
목적：탐토갑상선격소수평여수발화복발억욱증지간적상관성급림상의의。방법：채용전화학발광면역분석법，분별측정127례억욱증환자（기중수발억욱조66례、복발억욱조61례）화53명정상자（정상대조조）적혈청삼전갑상선원안산（ T3）、갑상선소（ T4）、유리갑상선격소（ FT3、FT4）화촉갑상선격소（ TSH）수평；채용한밀이돈억욱량표（ HAMD）평고환자억욱정도。결과：복발억욱조혈청FT3수평현저저우정상대조조（ P＝0?009），혈청T3、T4、FT4、TSH수평여정상대조조차이무통계학의의；수발억욱조혈청T3、T4、FT3、FT4、TSH수평여정상대조조차이무통계학의의。상관분석현시，수발억욱조혈청T3수평여HAMD총분정부상관（ r＝—0?250，P＝0?043）；복발억욱조혈청T3、T4、FT3、FT4、TSH여HAMD총분균무상관（r＝0?014~0?204，P균＞0?05）。결론：억욱증수차발병여복발환자혈청갑상선격소수평존재일정변화，복발교수발억욱자가능존재경엄중적갑상선공능감퇴。
Objective:To explore the relationship between serum thyroid hormones levels and major de_pression and clinical significance? Method:The serum triiodothyronine( T3 ),thyroxin( T4 ),free_triiodothy_ronine(T3),thyroxin(T4)and thyroid stimulating hormone(TSH)levels were measured by electrochemilumi_nescence immunoassay in 127 depressive patients( 66 cases in first_episode group and 61 cases in recurrent group)and 53 healthy controls( normal control group )? The degree of depression of all the patients were as_sessed by Hamilton depression scale( HAMD)? Results:The serum FT3 level in recurrent group was signifi_cantly lower than that in normal control group(P=0?009)?There were no significant differences in serum T3, T4,FT4 and TSH levels between recurrent group and normal control group?No significant differences were found in serum T3,T4,FT3,FT4 and TSH levels between first_episode group and normal control group?Correlation a_nalysis indicated that the total scores of HAMD were negatively associated with serum T3 levels in first_episode group(r= —0?250,P=0?043)?The total scores of HAMD were not related to serum T3,T4,FT3,FT4,TSH levels in recurrent group(r=0?014~0?204,all P>0?05)? Conclusion:The changes of serum thyroid hor_mones level were found in first_episode and recurrent depressive patients,and recurrent depressive patients may have more severe thyroid dysfunction.