CAJ | 학술논문

目的：比较胃癌合并与不合并抑郁症患者和健康人血浆Nesfatin_1浓度的差异，以及与抑郁严重程度的相关性。方法：采用抑郁自评量表（ SDS）和汉密尔顿抑郁量表（ HAMD）对16例胃癌合并抑郁症患者（ GCD组）、18例胃癌不合并抑郁症患者（ GCND组）及26名健康对照（正常对照组）进行评定，同时检测血浆皮质醇及Nesfatin_1浓度，对其浓度与抑郁严重程度相关性进行分析。结果：血浆Nesfatin_1浓度GCD组显著低于GCND组（P＜0?05），且两组Nesfatin_1浓度均低于正常对照组（P均＜0?001）；血浆皮质醇浓度GCD组显著高于GCND组，但GCND组低于正常对照组（ P均＜0?001）。血浆Nesfatin_1浓度与 GCD 组的 SDS、HAMD 评分呈显著负相关（ r ＝—0?601，P ＝0?014；r ＝—0?528， P＝0?035），而与血浆皮质醇浓度不相关（ r＝—0?109，P＝0?687）。结论：胃癌合并抑郁症患者的血浆Nesfatin_1浓度显著降低，并与胃癌合并抑郁症的发病、以及抑郁严重程度相关。
목적：비교위암합병여불합병억욱증환자화건강인혈장Nesfatin_1농도적차이，이급여억욱엄중정도적상관성。방법：채용억욱자평량표（ SDS）화한밀이돈억욱량표（ HAMD）대16례위암합병억욱증환자（ GCD조）、18례위암불합병억욱증환자（ GCND조）급26명건강대조（정상대조조）진행평정，동시검측혈장피질순급Nesfatin_1농도，대기농도여억욱엄중정도상관성진행분석。결과：혈장Nesfatin_1농도GCD조현저저우GCND조（P＜0?05），차량조Nesfatin_1농도균저우정상대조조（P균＜0?001）；혈장피질순농도GCD조현저고우GCND조，단GCND조저우정상대조조（ P균＜0?001）。혈장Nesfatin_1농도여 GCD 조적 SDS、HAMD 평분정현저부상관（ r ＝—0?601，P ＝0?014；r ＝—0?528， P＝0?035），이여혈장피질순농도불상관（ r＝—0?109，P＝0?687）。결론：위암합병억욱증환자적혈장Nesfatin_1농도현저강저，병여위암합병억욱증적발병、이급억욱엄중정도상관。
Objective:To explore plasma Nesfatin_1 level in gastric cancer patients with or without de_pression,and its relationship with the degree of depression? Method:The sixteen gastric cancer patients with depression( GCD group),18 gastric cancer patients without depression( GCND group)and 26 healthy controls ( NC group)were assessed with self depression scale( SDS)and Hamilton depression scale( HAMD)?Wihle plasma Nesfatin_1 and cortisol levels were detected?The correlation among those levels and the degrees of de_pression were analyzed? Results:The level of plasma Nesfatin_1 in GCD group was significantly lower than GCND group(P<0?05),and both of the two groups were significantly lower than NC group(all P<0?01)?The levels of plasma cortisol in GCD group were significantly higher than GCND group(P<0?001),but which in GCND group was significantly lower than NC group( P<0?01 )? The plasam Nesfatin_1 levels in GCD was negatively correlated with SDS score(r= —0?601,P=0?014)and HAMD score(r= —0?528,P=0?035);while there was no correlation with plasam cortisol level(r= —0?109,P=0?687)? Conclusion:Plasma Nes_fatin_1 level in gastric cancer patients with depression is significantly reduced?It may be related to the pathogen_esis and severity of depression in gastric cancer patients with depression.