口腔颌面外科杂志
口腔頜麵外科雜誌
구강합면외과잡지
CHINESE JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY
2014年
6期
401-404
,共4页
E3泛素连接酶%热休克蛋白70碳末端相互作用蛋白(CHIP)%上皮性癌
E3汎素連接酶%熱休剋蛋白70碳末耑相互作用蛋白(CHIP)%上皮性癌
E3범소련접매%열휴극단백70탄말단상호작용단백(CHIP)%상피성암
E3 ubiquitin ligase%carboxy terminus of Hsc70 interacting protein (CHIP)%epithelial cancer
泛素化修饰是机体一种非常重要的蛋白质翻译后修饰方式，其广泛参与细胞周期、DNA修复、信号转导、转录调控等生物学过程。近些年，蛋白质泛素化修饰在恶性肿瘤发生和发展中的作用，受到国内外广泛关注。尤其是E3泛素连接酶，它能特异性识别作用底物，泛素化修饰的特异性就取决于该连接酶。研究表明，E3泛素连接酶功能异常与恶性肿瘤等多种疾病的病理过程密切相关，因此分析特定的E3连接酶在恶性肿瘤中的作用和机制，有助于加深对恶性肿瘤发生、发展过程中分子机制的认识，为恶性肿瘤相关分子分类和治疗靶点提供实验基础。本文对E3泛素连接酶CHIP的功能，尤其与上皮性癌关系的研究进展进行综述。
汎素化脩飾是機體一種非常重要的蛋白質翻譯後脩飾方式，其廣汎參與細胞週期、DNA脩複、信號轉導、轉錄調控等生物學過程。近些年，蛋白質汎素化脩飾在噁性腫瘤髮生和髮展中的作用，受到國內外廣汎關註。尤其是E3汎素連接酶，它能特異性識彆作用底物，汎素化脩飾的特異性就取決于該連接酶。研究錶明，E3汎素連接酶功能異常與噁性腫瘤等多種疾病的病理過程密切相關，因此分析特定的E3連接酶在噁性腫瘤中的作用和機製，有助于加深對噁性腫瘤髮生、髮展過程中分子機製的認識，為噁性腫瘤相關分子分類和治療靶點提供實驗基礎。本文對E3汎素連接酶CHIP的功能，尤其與上皮性癌關繫的研究進展進行綜述。
범소화수식시궤체일충비상중요적단백질번역후수식방식，기엄범삼여세포주기、DNA수복、신호전도、전록조공등생물학과정。근사년，단백질범소화수식재악성종류발생화발전중적작용，수도국내외엄범관주。우기시E3범소련접매，타능특이성식별작용저물，범소화수식적특이성취취결우해련접매。연구표명，E3범소련접매공능이상여악성종류등다충질병적병리과정밀절상관，인차분석특정적E3련접매재악성종류중적작용화궤제，유조우가심대악성종류발생、발전과정중분자궤제적인식，위악성종류상관분자분류화치료파점제공실험기출。본문대E3범소련접매CHIP적공능，우기여상피성암관계적연구진전진행종술。
Ubiquitin modification is termed as an important way for the post-translational regulation of cellular protein, which is found involved in a serial of biological process, such as cell cycle, DNA repair signaling transduction, transcriptional regulation, and so on. Recently, ubiquitin modifications occurred in the malignant tumors have been observed and studied broadly. The specificity of ubiquitin modification rely on the E3 ubiquitin ligases for its specific action with certain substrates, dysfunction of which is shown to be related to the pathological processes of many diseases, including malignant tumors. The further analysis for the function of E3 ubiquitin ligases will strengthen our knowledge on the molecular mechanisms of carcinogenesis and development of malignant tumors, which might also provide biological targets for molecular classification and clinical treatment. Now a review was conducted for the function of one E3 ubiquitin ligase, carboxy terminus of Hsc70 interacting protein (CHIP), especially for its relationship with epithelial cancers.
