CAJ | 학술논문

研究了以1,4-丁二醇二缩水甘油醚作为交联剂，透明质酸钠为原料，制备交联透明质酸钠凝胶。探讨了氢氧化钠浓度、反应温度、反应时间对交联透明质酸钠凝胶中残留量的影响。实验结果表明，反应最佳条件为：氢氧化钠浓度0.25mol/L，50℃反应4小时，20℃反应3天时间。此方法制备的交联透明质酸钠凝胶中交联剂残留量低于2μg/g，所需水洗时间短，产品符合YY 0308-2004标准。
연구료이1,4-정이순이축수감유미작위교련제，투명질산납위원료，제비교련투명질산납응효。탐토료경양화납농도、반응온도、반응시간대교련투명질산납응효중잔류량적영향。실험결과표명，반응최가조건위：경양화납농도0.25mol/L，50℃반응4소시，20℃반응3천시간。차방법제비적교련투명질산납응효중교련제잔류량저우2μg/g，소수수세시간단，산품부합YY 0308-2004표준。
Cross-linked hyaluronic acid gel were prepared by 1, 4-butanediol diglycidyl ether and hyaluronic acid. Through the investigation of sodium concentration reaction temperature, reaction time is determined to optimize the optimal conditions. Sodium concentration 0.25mol/L, high temperature 50℃, reaction time 4 hours, low temperature 20℃, reaction time 3 days. The crosslinking agent residue is less than 2μg /g with method. The washing time is short. The cross-linked sodium hyaluronate were tested in accordance with YY 0308-2004 standards.