CAJ | 학술논문

目的：探讨血氧水平依赖磁共振成像（BOLD MRI）在诊断肾功能不全以及鉴别不同分级肾功能不全的应用价值。方法对15名健康志愿者和55名不同分级肾功能不全患者进行BOLD M RI扫描，测量各组肾脏皮质、髓质的R2*值并计算髓质／皮质R2*值，对比分析各组数据。结果①正常对照组及不同分级的肾功能不全患者的皮质、髓质以及髓质／皮质R2*值间均存在统计学差异（ P ＜0．05）；②皮质R2*值与肾功能分级呈正相关，而髓质R2*值及髓质／皮质R2*比值与肾功能分级呈负相关。结论血氧水平依赖磁共振成像作为反映肾脏功能改变程度的敏感指标在肾功能不全的诊断及分级鉴别中起到重要的作用。
목적：탐토혈양수평의뢰자공진성상（BOLD MRI）재진단신공능불전이급감별불동분급신공능불전적응용개치。방법대15명건강지원자화55명불동분급신공능불전환자진행BOLD M RI소묘，측량각조신장피질、수질적R2*치병계산수질／피질R2*치，대비분석각조수거。결과①정상대조조급불동분급적신공능불전환자적피질、수질이급수질／피질R2*치간균존재통계학차이（ P ＜0．05）；②피질R2*치여신공능분급정정상관，이수질R2*치급수질／피질R2*비치여신공능분급정부상관。결론혈양수평의뢰자공진성상작위반영신장공능개변정도적민감지표재신공능불전적진단급분급감별중기도중요적작용。
Objective To explore the application value of blood oxygen level dependent functional magnetic resonance im‐aging (BOLD MRI) in the diagnosis of renal insufficiency and classification renal insufficiency in different grades .Methods Blood oxygen level dependent magnetic resonance imaging was used on 15 healthy volunteers and 55 renal insufficiency pa‐tients of different grades ,cortical ,medullary ,medulla/cortex R2 * values were measured and compared in each group .Re‐sults ① There were significant differences between R2 * values of the normal control group and different grades of renal insufficiency patients with cortical ,medullary and cortical/medulla ( P <0 .05);② In the patients with renal insufficien‐cy ,R2 * values of cortex were proportional to renal insufficiency level ,whereas ,values of medulla and medulla/cortex were in the opposite .Conclusion This research shows that blood oxygen level dependent magnetic resonance imaging can reflect the changes of renal function sensitively and play an important role in the diagnosis and staging of renal insufficien‐cy .