医学影像学杂志
醫學影像學雜誌
의학영상학잡지
JOURNAL OF MEDICAL IMAGING
2014年
11期
1954-1956
,共3页
孟凡银%张晓%白朝霞%邢宁
孟凡銀%張曉%白朝霞%邢寧
맹범은%장효%백조하%형저
VHL基因%肾透明细胞癌%体层摄影术 ,X线计算机%Sanger测序
VHL基因%腎透明細胞癌%體層攝影術 ,X線計算機%Sanger測序
VHL기인%신투명세포암%체층섭영술 ,X선계산궤%Sanger측서
VHLgene%Renal clear cell carcinoma%Tomography,X-ray computed%Sanger sequencing
目的:探讨(von hippel‐lindau ,VHL)基因与肾透明细胞癌CT影像学特点的关系。方法本研究以中国肾透明细胞癌患者为研究对象,提取基因组DNA、应用聚合酶链反应扩增 VHL基因片段后进行Sanger测序,结合CT 影像学表现进行相关分析。结果98例肾透明细胞癌患者纳入本研究,其中53例(54.1%)患者存在 V H L 基因突变。VHL基因突变在肿瘤边缘清晰( P =0.041)与否及肿瘤内是否有新生血管形成( P =0.006)有显著差异。结论 VHL基因突变可影响肾透明细胞癌CT影像学表现。
目的:探討(von hippel‐lindau ,VHL)基因與腎透明細胞癌CT影像學特點的關繫。方法本研究以中國腎透明細胞癌患者為研究對象,提取基因組DNA、應用聚閤酶鏈反應擴增 VHL基因片段後進行Sanger測序,結閤CT 影像學錶現進行相關分析。結果98例腎透明細胞癌患者納入本研究,其中53例(54.1%)患者存在 V H L 基因突變。VHL基因突變在腫瘤邊緣清晰( P =0.041)與否及腫瘤內是否有新生血管形成( P =0.006)有顯著差異。結論 VHL基因突變可影響腎透明細胞癌CT影像學錶現。
목적:탐토(von hippel‐lindau ,VHL)기인여신투명세포암CT영상학특점적관계。방법본연구이중국신투명세포암환자위연구대상,제취기인조DNA、응용취합매련반응확증 VHL기인편단후진행Sanger측서,결합CT 영상학표현진행상관분석。결과98례신투명세포암환자납입본연구,기중53례(54.1%)환자존재 V H L 기인돌변。VHL기인돌변재종류변연청석( P =0.041)여부급종류내시부유신생혈관형성( P =0.006)유현저차이。결론 VHL기인돌변가영향신투명세포암CT영상학표현。
Objective To investigate the relationship between Von Hippel‐Lindau (VHL) gene and the CT imaging char‐acteristics of renal clear cell carcinoma .Methods This research was conducted to understand renal clear cell carcinoma pa‐tients in China with the genomic DNA extraction ,and analyzed the VHLgenetic fragment amplified by Polymerase Chain Reaction (PCR) based Sanger sequencing ,and compared with CT imaging .Results In all ,98 renal clear cell carcinoma patients were identified ,VHL gene mutation was detected in 53(54 .1% ) of eligible patients .VHL gene mutation around the tumor tissue with a clear edge or not ( P=0 .041) showed significant difference from neovascularization ( P=0 .006) . Conclusion VHL gene mutation could affect CT imageing manifestations of renal clear cell carcinoma .