中国药物与临床
中國藥物與臨床
중국약물여림상
CHINESE REMEDIES & CLINICS
2014年
12期
1616-1619
,共4页
高飞%李伟%葛志敏%师天燕%杨静
高飛%李偉%葛誌敏%師天燕%楊靜
고비%리위%갈지민%사천연%양정
骨质疏松,绝经后%骨密度%腰椎%胰岛素
骨質疏鬆,絕經後%骨密度%腰椎%胰島素
골질소송,절경후%골밀도%요추%이도소
Osteoporosis,postmenopausal%Bone density%Lumbar vertebrae%Insulin
目的：探讨绝经后女性相关代谢指标与骨矿密度（BMD）及校正骨矿含量（cBMC）的关系。方法195例绝经后女性测量身高、体质量、腰围（W）、臀围（H）、收缩压（SBP）、舒张压（DBP），计算体质量指数（BMI）；测定空腹血糖（FBG）、空腹胰岛素（FINS）、甘油三酯（TG）、总胆固醇（TC）、高密度脂蛋白（HDL）、低密度脂蛋白（LDL）、腰椎骨密度，计算HOMA-胰岛素抵抗指数（HOMA-IR）、校正骨矿含量，分析相关代谢指标与BMD、cBMC的相关性，并分析各因素对二者的影响。结果①腰椎（L）1～4 BMD与年龄、绝经年限、TC、LDL呈负相关，与BMI、W、FINS、HOMA-IR、HDL呈正相关；L1～4 cBMC与年龄、绝经年限、TC、LDL、HOMA-IR呈负相关，与FINS、HDL呈正相关；②以L1～4 BMD为应变量行多重线性回归，年龄、BMI、LDL、HDL、W对其有影响；以L1～4 cBMC为应变量行多重线性回归，年龄、BMI、LDL、HDL、HOMA-IR对其有影响。结论①BMI与BMD呈正相关，与cBMC呈负相关，故肥胖患者发生骨折的危险性增高；②血胰岛素水平与BMD呈正相关，胰岛素抵抗与cBMC呈负相关，故胰岛素抵抗患者发生骨折的危险性增高；③LDL与BMD、cBMC呈负相关、HDL与BMD、cBMC呈正相关，高LDL、低HDL增加骨质疏松及骨折的发生。
目的：探討絕經後女性相關代謝指標與骨礦密度（BMD）及校正骨礦含量（cBMC）的關繫。方法195例絕經後女性測量身高、體質量、腰圍（W）、臀圍（H）、收縮壓（SBP）、舒張壓（DBP），計算體質量指數（BMI）；測定空腹血糖（FBG）、空腹胰島素（FINS）、甘油三酯（TG）、總膽固醇（TC）、高密度脂蛋白（HDL）、低密度脂蛋白（LDL）、腰椎骨密度，計算HOMA-胰島素牴抗指數（HOMA-IR）、校正骨礦含量，分析相關代謝指標與BMD、cBMC的相關性，併分析各因素對二者的影響。結果①腰椎（L）1～4 BMD與年齡、絕經年限、TC、LDL呈負相關，與BMI、W、FINS、HOMA-IR、HDL呈正相關；L1～4 cBMC與年齡、絕經年限、TC、LDL、HOMA-IR呈負相關，與FINS、HDL呈正相關；②以L1～4 BMD為應變量行多重線性迴歸，年齡、BMI、LDL、HDL、W對其有影響；以L1～4 cBMC為應變量行多重線性迴歸，年齡、BMI、LDL、HDL、HOMA-IR對其有影響。結論①BMI與BMD呈正相關，與cBMC呈負相關，故肥胖患者髮生骨摺的危險性增高；②血胰島素水平與BMD呈正相關，胰島素牴抗與cBMC呈負相關，故胰島素牴抗患者髮生骨摺的危險性增高；③LDL與BMD、cBMC呈負相關、HDL與BMD、cBMC呈正相關，高LDL、低HDL增加骨質疏鬆及骨摺的髮生。
목적：탐토절경후녀성상관대사지표여골광밀도（BMD）급교정골광함량（cBMC）적관계。방법195례절경후녀성측량신고、체질량、요위（W）、둔위（H）、수축압（SBP）、서장압（DBP），계산체질량지수（BMI）；측정공복혈당（FBG）、공복이도소（FINS）、감유삼지（TG）、총담고순（TC）、고밀도지단백（HDL）、저밀도지단백（LDL）、요추골밀도，계산HOMA-이도소저항지수（HOMA-IR）、교정골광함량，분석상관대사지표여BMD、cBMC적상관성，병분석각인소대이자적영향。결과①요추（L）1～4 BMD여년령、절경년한、TC、LDL정부상관，여BMI、W、FINS、HOMA-IR、HDL정정상관；L1～4 cBMC여년령、절경년한、TC、LDL、HOMA-IR정부상관，여FINS、HDL정정상관；②이L1～4 BMD위응변량행다중선성회귀，년령、BMI、LDL、HDL、W대기유영향；이L1～4 cBMC위응변량행다중선성회귀，년령、BMI、LDL、HDL、HOMA-IR대기유영향。결론①BMI여BMD정정상관，여cBMC정부상관，고비반환자발생골절적위험성증고；②혈이도소수평여BMD정정상관，이도소저항여cBMC정부상관，고이도소저항환자발생골절적위험성증고；③LDL여BMD、cBMC정부상관、HDL여BMD、cBMC정정상관，고LDL、저HDL증가골질소송급골절적발생。
Objective To investigate the relationship among major metabolic indexes, bone mineral density (BMD) and correcting bone mineral content (cBMC) in postmenopausal women. Methods The height, weight, waist-line (W), hipline (H), systolic blood pressure (SBP), diastolic blood pressure (DBP) of 195 postmenopausal women were measured and their body mass index (BMI) were calculated. The fasting blood glucose (FBG), fasting insulin (FINS), triglyceride (TG), total cholesterol (TC), high density lipoprotein (HDL), low density lipoprotein (LDL), and lumbar vertebrae bone mineral density of these patients were determined, and then, HOMA-insulin resistance index (HOMA-IR) and cBMC were calculated. The correlation among major metabolic indexes, BMD and cBMC were ana-lyzed, and the influences of these factors on BMD and cBMC were analyzed. Results ①L1-4 BMD were negatively correlated with age, menopausal years, TC and LDL, while positively correlated with BMI, W, FINS, HOMA-IR and HDL. ②In multiple linear regression models, the effect factors L 1-4 BMD as the dependent variable were age, BMI, LDL, HDL and W; the effect factors L1-4 cBMC as the dependent variable were age, BMI, LDL, HDL and HOMA-IR. Conclusion ①BMI was positively correlated with BMD and negatively correlated with cBMC. Hence, obese patients have increased risk for fractures. ②Serum insulin level was positively correlated with BMD, while insulin resistance was negatively correlated with cBMC. Therefore, patients with insulin resistance have higher risk for fractures. ③LDL was negatively correlated with BMD and cBMC. HDL was positively correlated with BMD and cBMC. High LDL and low HDL levels may increase the incidence of osteoporosis and fracture.
