中国免疫学杂志
中國免疫學雜誌
중국면역학잡지
CHINESE JOURNAL OF IMMUNOLOGY
2014年
12期
1701-1704
,共4页
血清胱抑素C%晚期氧化蛋白产物%早发子痫前期%妊娠结局
血清胱抑素C%晚期氧化蛋白產物%早髮子癇前期%妊娠結跼
혈청광억소C%만기양화단백산물%조발자간전기%임신결국
Serum cystatin C%AOPP%Early preeclampsia pregnancy%Pregnancy outcome
目的:探讨血清晚期氧化蛋白产物( Advanced oxidation protein products ,AOPP)以及胱抑素C( Cystatin C,Cys-C)与维吾尔族早发型子痫前期的妊娠结局的相关性。方法:分析2011年5月至2013年5月在我院妇产科接受治疗且分娩的75例维吾尔族早发型子痫前期患者的临床资料,对照组为同期在我院接受产前检查的60例维吾尔族正常孕妇。比较子痫前期患者与正常对照组的AOPP及Cys-C水平差异,并对不同严重程度、不同妊娠结局的早发子痫前期患者的临床资料、不良妊娠结果(包括子痫、羊水过少、胎儿窒息、胎盘早剥、胎儿生长受限、HELLP综合征等)进行比较。结果:本研究共纳入维吾尔族孕妇135例,其中子痫前期患者75例(包括轻度组35例,重度组40例),正常对照组孕妇60例。子痫前期患者的SBP ( t=3.410,P<0.01)、Cys-C(t=4.586,P<0.01)、AOPP(t=7.980,P<0.01)水平均显著高于正常对照组;轻度组患者的SBP(t=3.992,P<0.01)、Cys-C(t=4.126,P<0.01)、UA(t=4.817,P<0.01)、Cr(t=7.848,P<0.01)、AOPP(t=6.540,P<0.01)值均显著低于重度组;轻度组患者出现羊水过少(χ2=4.688,P=0.030)、胎盘早剥(χ2=5.195,P=0.023)、胎儿生长受限(χ2=7.252, P<0.01)、HELLP综合征(χ2=4.688,P=0.030)的概率均低于重度组,差异均具有统计学意义;结局不良组患者的Cys-C ( t=5.234,P<0.01)、尿酸(t=3.337, P<0.01)、Cr(t=3.745,P<0.01)、AOPP(t=6.540,P<0.01)水平均显著高于良好组。结论:维吾尔族早发子痫前期患者的Cys-C水平明显上升,且Cys-C及AOPP水平与患者的妊娠结局有着重要的相关性。
目的:探討血清晚期氧化蛋白產物( Advanced oxidation protein products ,AOPP)以及胱抑素C( Cystatin C,Cys-C)與維吾爾族早髮型子癇前期的妊娠結跼的相關性。方法:分析2011年5月至2013年5月在我院婦產科接受治療且分娩的75例維吾爾族早髮型子癇前期患者的臨床資料,對照組為同期在我院接受產前檢查的60例維吾爾族正常孕婦。比較子癇前期患者與正常對照組的AOPP及Cys-C水平差異,併對不同嚴重程度、不同妊娠結跼的早髮子癇前期患者的臨床資料、不良妊娠結果(包括子癇、羊水過少、胎兒窒息、胎盤早剝、胎兒生長受限、HELLP綜閤徵等)進行比較。結果:本研究共納入維吾爾族孕婦135例,其中子癇前期患者75例(包括輕度組35例,重度組40例),正常對照組孕婦60例。子癇前期患者的SBP ( t=3.410,P<0.01)、Cys-C(t=4.586,P<0.01)、AOPP(t=7.980,P<0.01)水平均顯著高于正常對照組;輕度組患者的SBP(t=3.992,P<0.01)、Cys-C(t=4.126,P<0.01)、UA(t=4.817,P<0.01)、Cr(t=7.848,P<0.01)、AOPP(t=6.540,P<0.01)值均顯著低于重度組;輕度組患者齣現羊水過少(χ2=4.688,P=0.030)、胎盤早剝(χ2=5.195,P=0.023)、胎兒生長受限(χ2=7.252, P<0.01)、HELLP綜閤徵(χ2=4.688,P=0.030)的概率均低于重度組,差異均具有統計學意義;結跼不良組患者的Cys-C ( t=5.234,P<0.01)、尿痠(t=3.337, P<0.01)、Cr(t=3.745,P<0.01)、AOPP(t=6.540,P<0.01)水平均顯著高于良好組。結論:維吾爾族早髮子癇前期患者的Cys-C水平明顯上升,且Cys-C及AOPP水平與患者的妊娠結跼有著重要的相關性。
목적:탐토혈청만기양화단백산물( Advanced oxidation protein products ,AOPP)이급광억소C( Cystatin C,Cys-C)여유오이족조발형자간전기적임신결국적상관성。방법:분석2011년5월지2013년5월재아원부산과접수치료차분면적75례유오이족조발형자간전기환자적림상자료,대조조위동기재아원접수산전검사적60례유오이족정상잉부。비교자간전기환자여정상대조조적AOPP급Cys-C수평차이,병대불동엄중정도、불동임신결국적조발자간전기환자적림상자료、불량임신결과(포괄자간、양수과소、태인질식、태반조박、태인생장수한、HELLP종합정등)진행비교。결과:본연구공납입유오이족잉부135례,기중자간전기환자75례(포괄경도조35례,중도조40례),정상대조조잉부60례。자간전기환자적SBP ( t=3.410,P<0.01)、Cys-C(t=4.586,P<0.01)、AOPP(t=7.980,P<0.01)수평균현저고우정상대조조;경도조환자적SBP(t=3.992,P<0.01)、Cys-C(t=4.126,P<0.01)、UA(t=4.817,P<0.01)、Cr(t=7.848,P<0.01)、AOPP(t=6.540,P<0.01)치균현저저우중도조;경도조환자출현양수과소(χ2=4.688,P=0.030)、태반조박(χ2=5.195,P=0.023)、태인생장수한(χ2=7.252, P<0.01)、HELLP종합정(χ2=4.688,P=0.030)적개솔균저우중도조,차이균구유통계학의의;결국불량조환자적Cys-C ( t=5.234,P<0.01)、뇨산(t=3.337, P<0.01)、Cr(t=3.745,P<0.01)、AOPP(t=6.540,P<0.01)수평균현저고우량호조。결론:유오이족조발자간전기환자적Cys-C수평명현상승,차Cys-C급AOPP수평여환자적임신결국유착중요적상관성。
Objective:To discuss the relationship between serum advanced oxidation protein products (AOPP)and cystatin C with the early preeclampsia pregnancy outcome.Methods:Clinical data of 75 patients received treatment and labor at our hospital from 2011 to 2013 was retrospectively analyzed.The control group included 60 normal pregnant women who received prenatal examination in our hospital at the same time.The difference in cystatin C and AOPP level of the patients with preeclampsia and the normal group was compared.The clinical data and the adverse pregnancy outcome of the patients with preeclampsia in different severity and different outcome of pregnancy were compared.Results:A total of 135 patients were retrospective analyzed ,including 75 in observe group and 60 in control group.The SBP level in the patients with preeclampsia is obviously higher than in the normal group .The level of SB,UA,Cr and AOPP in the patients of mild group is obviously lower than in the severe group.The incidence of oligohydramnios , placental abruption,fetal growth restriction and HELLP syndrome in the patients of mild group was obviously lower than in the severe group .The differences were statistically significant.The level of cystatin C,UA,Cr and AOPP in the patients of adverse pregnancy outcome were obviously higher than in the group of good outcome of pregnancy.Conclusion:The cystatin C and AOPP level of the early preeclampsia patients is obviously increased and it has significant correlation with the pregnancy outcome in patients .