CAJ | 학술논문

目的：探讨SEPTIN 9在胃癌组织中的表达及临床意义。方法从我院内镜室收集102例胃癌组织及其癌旁组织标本，通过组织微阵列和免疫组织化学染色方法检测胃癌及其癌旁组织中SEPTIN 9蛋白表达水平，并结合相应的病理资料，分析SEPTIN 9与胃癌组织分化程度的关系。结果在102例胃癌组织中，84例（82．4％）SEPTIN 9表达阳性；在102例癌旁组织中，35例（34．3％）表达阳性，胃癌组织中SEPTIN 9的阳性表达率显著高于癌旁组织（χ2＝48．424，P＝0．000）。在58例高中分化胃癌组织中，23例（39．6％）SEPTIN 9高表达，在44例低分化胃癌组织中，40例（90．9％）SEPTIN 9高表达，二者高表达率有显著性差异（χ2＝27．931，P＝0．000）。结论 SEPTIN 9在胃癌组织中高达，且与胃癌的分化程度有关。
목적：탐토SEPTIN 9재위암조직중적표체급림상의의。방법종아원내경실수집102례위암조직급기암방조직표본，통과조직미진렬화면역조직화학염색방법검측위암급기암방조직중SEPTIN 9단백표체수평，병결합상응적병리자료，분석SEPTIN 9여위암조직분화정도적관계。결과재102례위암조직중，84례（82．4％）SEPTIN 9표체양성；재102례암방조직중，35례（34．3％）표체양성，위암조직중SEPTIN 9적양성표체솔현저고우암방조직（χ2＝48．424，P＝0．000）。재58례고중분화위암조직중，23례（39．6％）SEPTIN 9고표체，재44례저분화위암조직중，40례（90．9％）SEPTIN 9고표체，이자고표체솔유현저성차이（χ2＝27．931，P＝0．000）。결론 SEPTIN 9재위암조직중고체，차여위암적분화정도유관。
Objective To explore the clinical significance of SEPTIN 9 expression in gastric cancer(GC)tissues. Methods A total of 102 GC tissues and 102 para-cancer tissues from surgical resected specimen were included in this study. Tissue microarray and immunohistochemistry(IHC) were used to detect SEPTIN 9 protein expression in the tissues. The clinical pathological data were collected for reviewing the relation between SEPTIN 9 expression and tissue differentiation. Results The SEPTIN 9 protein was mainly expressed in the cytoplasm. The expression rate in GC tissues was significantly higher than that in para-cancer normal tissues (82.4%vs.34.3%,χ2 =48.424, P=0.000).The SEPTIN 9 protein overexpression rate in lowly differentiated GC tissues was significantly higher than that in highly and moderately differentiated GC tissues (90.9%vs.39.6%,χ2 =27.931, P=0.000). Conclusions The level of SEPTIN 9 protein is higher in GC tissues than that in para-cancer normal tissues. The expression of SEPTIN 9 protein is associated with the degree of cancer differentiation.