CAJ | 학술논문

目的：探讨CD133、肝细胞生长因子（hepatocyte growth factor，HGF）和垂体肿瘤转化基因（pituitary tumor transforming gene，PTTG）在大肠癌患者肿瘤组织、肿瘤旁正常组织和淋巴结中的表达及其与肿瘤患者临床之间的关系。方法应用免疫组化法检测70例大肠癌患者的肿瘤组织、肿瘤旁的正常组织和淋巴结，分别检测CD133、HGF、PTTG的表达情况。结果 CD133、HGF、PTTG三种蛋白均在肿瘤组织中高表达，且表达均与大肠癌的淋巴结转移及术后生存期有关（P＜0．05），而与患者性别、年龄、肿瘤发生部位、临床病理分期及肿瘤大小无关（P＞0．05）；三种蛋白的表达两两之间无相关性。结论 CD133、HGF、PTTG三种蛋白对于大肠癌的诊断及鉴别诊断有一定的意义；三种蛋白的表达对大肠癌患者的术后复发、转移及其预后可能有指导意义。
목적：탐토CD133、간세포생장인자（hepatocyte growth factor，HGF）화수체종류전화기인（pituitary tumor transforming gene，PTTG）재대장암환자종류조직、종류방정상조직화림파결중적표체급기여종류환자림상지간적관계。방법응용면역조화법검측70례대장암환자적종류조직、종류방적정상조직화림파결，분별검측CD133、HGF、PTTG적표체정황。결과 CD133、HGF、PTTG삼충단백균재종류조직중고표체，차표체균여대장암적림파결전이급술후생존기유관（P＜0．05），이여환자성별、년령、종류발생부위、림상병리분기급종류대소무관（P＞0．05）；삼충단백적표체량량지간무상관성。결론 CD133、HGF、PTTG삼충단백대우대장암적진단급감별진단유일정적의의；삼충단백적표체대대장암환자적술후복발、전이급기예후가능유지도의의。
Objective To evaluate the expressions of CD133,hepatocyte growth factor(HGF)andpituitary tumor transforming gene(PTTG)expressed in colorectal tumor tissues,adjacent normal tissues andlymph nodes and its clinical correlation in patients with colorectal tumor.Methods A total of 70 cases ofcolorectal cancer patients were enrolled.The expressions of CD133,HGF and PTTG in tumor tissues,adjacent normal tissues and lymph nodes were tested by immunohistochemistry.Results CD133,HGF andPTTG were highly expressed in tumor tissues.They were closely related to metastasis and postoperative survivals(P <0.05),but had no relevance with gender,age,clinical stage and tumor size(P >0.05).No correlation was observed among these indicators.Conclusion CD133,HGF and PTTG may be valuable forthe diagnosis and differential diagnosis of colorectal carcinoma.Their expressions may have guiding significance in recurrence,metastasis and prognosis for patients with colorectal cancer.