CAJ | 학술논문

尽管OCT早已在世界范围内获得临床诊断许可，但这项技术尚无任何国际标准。如何验证OCT的成像能力及有效性被认为是该技术标准化进程中的重要一环。本研究研制了一种可用于OCT三维成像分辨率测试的模拟眼。该模拟眼利用透明树脂材料仿真了人眼的重要光学元件：角膜与晶状体。采用3D 打印技术在模拟眼眼底制作出了参照 USAF1951靶板设计的三维分辨率测试图案。研究结果表明该模拟眼能够对 OCT 设备的三维成像分辨率性能进行初步评估，通过进一步改进，未来可用于注册检验或日常质控。
진관OCT조이재세계범위내획득림상진단허가，단저항기술상무임하국제표준。여하험증OCT적성상능력급유효성피인위시해기술표준화진정중적중요일배。본연구연제료일충가용우OCT삼유성상분변솔측시적모의안。해모의안이용투명수지재료방진료인안적중요광학원건：각막여정상체。채용3D 타인기술재모의안안저제작출료삼조 USAF1951파판설계적삼유분변솔측시도안。연구결과표명해모의안능구대 OCT 설비적삼유성상분변솔성능진행초보평고，통과진일보개진，미래가용우주책검험혹일상질공。
Optical Coherence Tomography (OCT) has been widely employed as non-invasive 3D imaging diagnostic instrument, particularly in the field of ophthalmology. Although OCT has been approved for use in clinic in USA, Europe and Asia, international standardization of this technology is still in progress. Validation of OCT imaging capabilities is considered extremely important to ensure its effective use in clinical diagnoses. Phantom with appropriate test targets can assist to evaluate and calibrate imaging performance of OCT at both installation and throughout lifetime of the instrument. In this paper, we design and fabricate a physical model eye with 3D resolution test targets to characterize OCT imaging performance. The model eye was fabricated with transparent resin to simulate realistic ophthalmic testing environment, and most key optical elements including cornea, lens and vitreous body were realized. The test targets which mimic USAF 1951 test chart were fabricated on the fundus of the model eye by 3D printing technology. Differing from traditional two dimensional USAF1951 test chart, a group of patterns which have different thickness in depth were fabricated. By measuring the 3D test targets, axial resolution as well as lateral resolution of an OCT system can be evaluated at the same time with this model eye. To investigate this specialized model eye, it was measured by a scientific spectral domain OCT instrument and a clinical OCT system respectively. The results demonstrate that the model eye with 3D resolution test targets have the potential of qualitatively and quantitatively validating the performance of OCT systems.