CAJ | 학술논문

目的：探讨血小板平均体积（MPV）在急性胰腺炎（AP）患者中的动态变化及其在病情判断中的意义。方法血细胞分析仪动态检测44例AP患者的MPV，绘制受试者工作特征曲线（ROC）、计算MPV的曲线下面积（AUC）。另设相匹配的30例健康体检者作为阴性对照。结果AP组患者入院时MPV值较对照组明显升高（t=2.98，P<0.05），随病情变化可出现逐渐减低、持续高值；重症急性胰腺炎（SAP）组患者MPV值均明显高于轻型急性胰腺炎（MAP）组（t=3.87，P<0.01）；AP患者MPV的AUC为0.810，根据ROC曲线初步得MPV值高于13.11fL可预测AP病情。结论MPV能比较准确地反映AP患者病情的变化，可帮助判断预后与指导治疗。
목적：탐토혈소판평균체적（MPV）재급성이선염（AP）환자중적동태변화급기재병정판단중적의의。방법혈세포분석의동태검측44례AP환자적MPV，회제수시자공작특정곡선（ROC）、계산MPV적곡선하면적（AUC）。령설상필배적30례건강체검자작위음성대조。결과AP조환자입원시MPV치교대조조명현승고（t=2.98，P<0.05），수병정변화가출현축점감저、지속고치；중증급성이선염（SAP）조환자MPV치균명현고우경형급성이선염（MAP）조（t=3.87，P<0.01）；AP환자MPV적AUC위0.810，근거ROC곡선초보득MPV치고우13.11fL가예측AP병정。결론MPV능비교준학지반영AP환자병정적변화，가방조판단예후여지도치료。
Objective?To?treat?the?dynamical?changes?and?prognostic?values?of?mean?platelet?volume(MPV)in?patients?with?acute?pancreatitis(AP).?Methods?The?MPV?in?44?patients?with?AP?and?30?healthy?subjects?were?dynamically?determined?by?using?automatic?blood-counter?system.?The?receiver?operating?characteristic(ROC)curve?was?drawn?and?the?area?under?curve(AUC)was?compared.?Results?The?MPV?in?AP?group?was?higher?than?that?in?control?group, there was signiifcant difference between two groups,(t=2.98,?P<0.05).?Dynamic?determining?showed?gradually?lower?level?or?steadily?high?level?following?the?developing?of?patient’s?pathogenetic?condition.?Compared?with?the?mild?acute?pancreatitis(MAP)group,?the?MPV?in?severe?acute?pancreatitis?group increased signiifcantly(t=3.87,?P<0.01).?ROC?curve?showed?the?AUC?of?MPV?in?patients?with?AP?was?0.810.?According?to?ROC?curve,?we?derived?MPV>13.11?fL?to?predict?patient’s?condition?of?AP.?Conclusion?The MPV can more accurately relfect changes of pathogenetic condition in patients with AP, it?can?help?determine?prognosis?and?guide?treatment.