山东医药
山東醫藥
산동의약
SHANDONG MEDICAL JOURNAL
2014年
47期
1-4
,共4页
体质量指数%胰岛素样生长因子-1%活性氧%肥胖%不育症
體質量指數%胰島素樣生長因子-1%活性氧%肥胖%不育癥
체질량지수%이도소양생장인자-1%활성양%비반%불육증
body mass index%insulin-like growth factor-I%reactive oxygen species%obesity%infertility
目的：观察超重和肥胖不育患者精浆中胰岛素样生长因子-1（ IGF-1）、活性氧（ ROS）水平变化，并探讨其临床意义。方法随机抽样抽取227例男性，其中正常体质量已经生育者58例（正常已育组），正常体质量不育者50例（正常不育组），超重不育者60例（超重不育组），肥胖不育者59例（肥胖不育组），精液常规分析，采用ELISA法检测各组入选对象精浆中IGF-1、ROS。结果与正常已育组比较，正常不育组IGF-1水平降低，超重不育组及肥胖不育组IGF-1、ROS水平升高；与正常不育组比较，超重不育组及肥胖不育组IGF-1、ROS水平升高；与超重不育组比较，肥胖不育组IGF-1、ROS水平升高（P均＜0．05）。男性不育患者BMI与精液量呈负相关（B＝－0．17，P＜0．05），与精子畸形率呈正相关（B＝0．20，P＜0．05），与IGF-1呈正相关（B＝0．29，P＜0．05），与ROS呈正相关（B＝0．41，P＜0．05）；ROS与IGF-1呈正相关（B＝0．62，P＜0．05）；IGF-1与精子前向运动率呈正相关（B＝0．15，P＜0．05）。结论正常体质量不育患者精浆中IGF-1水平下降，超重和肥胖不育患者精浆中IGF-1、ROS水平升高，检测上述指标对于临床分析肥胖影响男性不育原因提供一定理论依据，也为临床治疗提供参考。
目的：觀察超重和肥胖不育患者精漿中胰島素樣生長因子-1（ IGF-1）、活性氧（ ROS）水平變化，併探討其臨床意義。方法隨機抽樣抽取227例男性，其中正常體質量已經生育者58例（正常已育組），正常體質量不育者50例（正常不育組），超重不育者60例（超重不育組），肥胖不育者59例（肥胖不育組），精液常規分析，採用ELISA法檢測各組入選對象精漿中IGF-1、ROS。結果與正常已育組比較，正常不育組IGF-1水平降低，超重不育組及肥胖不育組IGF-1、ROS水平升高；與正常不育組比較，超重不育組及肥胖不育組IGF-1、ROS水平升高；與超重不育組比較，肥胖不育組IGF-1、ROS水平升高（P均＜0．05）。男性不育患者BMI與精液量呈負相關（B＝－0．17，P＜0．05），與精子畸形率呈正相關（B＝0．20，P＜0．05），與IGF-1呈正相關（B＝0．29，P＜0．05），與ROS呈正相關（B＝0．41，P＜0．05）；ROS與IGF-1呈正相關（B＝0．62，P＜0．05）；IGF-1與精子前嚮運動率呈正相關（B＝0．15，P＜0．05）。結論正常體質量不育患者精漿中IGF-1水平下降，超重和肥胖不育患者精漿中IGF-1、ROS水平升高，檢測上述指標對于臨床分析肥胖影響男性不育原因提供一定理論依據，也為臨床治療提供參攷。
목적：관찰초중화비반불육환자정장중이도소양생장인자-1（ IGF-1）、활성양（ ROS）수평변화，병탐토기림상의의。방법수궤추양추취227례남성，기중정상체질량이경생육자58례（정상이육조），정상체질량불육자50례（정상불육조），초중불육자60례（초중불육조），비반불육자59례（비반불육조），정액상규분석，채용ELISA법검측각조입선대상정장중IGF-1、ROS。결과여정상이육조비교，정상불육조IGF-1수평강저，초중불육조급비반불육조IGF-1、ROS수평승고；여정상불육조비교，초중불육조급비반불육조IGF-1、ROS수평승고；여초중불육조비교，비반불육조IGF-1、ROS수평승고（P균＜0．05）。남성불육환자BMI여정액량정부상관（B＝－0．17，P＜0．05），여정자기형솔정정상관（B＝0．20，P＜0．05），여IGF-1정정상관（B＝0．29，P＜0．05），여ROS정정상관（B＝0．41，P＜0．05）；ROS여IGF-1정정상관（B＝0．62，P＜0．05）；IGF-1여정자전향운동솔정정상관（B＝0．15，P＜0．05）。결론정상체질량불육환자정장중IGF-1수평하강，초중화비반불육환자정장중IGF-1、ROS수평승고，검측상술지표대우림상분석비반영향남성불육원인제공일정이론의거，야위림상치료제공삼고。
Objective To observe the change of insulin-like growth factor 1 ( IGF-1 ) and reactive oxygen species ( ROS) levels in the seminal plasma of overweight and obese patients with infertility , and to explore its clinical signifi-cance.Methods 227 male patients were randomly selected .They were divided into normal fertile group (58 cases who had normal weight and one or more children ), normal infertility group(50 cases who had normal weight but nfertility ), o-verweigh infertility group(60 cases who had overweight and nfertility ) and obese infertility group(59 cases who were obese and nfertility).Semen specimen was performed by conventional analysis .The levels of seminal plasma IGF-1 and ROS were detected by ELISA .Results Compared with normal fertile group , the level of IGF-1 in seminal plasma of normal in-fertility group decreased (all P<0.05).Compared with normal fertile group and normal infertility group , the levels of IGF-1 and ROS in seminal plasma of obese infertility group and overweight infertility group increased (all P<0.05).Com-pared with overweight infertility group, the levels of IGF-1 and ROS in obese infertility group increased(all P<0.05).In all the male infertility patients, BMI had negative correlation with sperm volume (B=0.17, P<0.05), positive correlation with sperm malformation rate(B=0.20, P<0.05), positive correlation with IGF-1(B=0.285, P<0.05), and positive correlation with ROS(B=0.414, P<0.05).ROS and IGF-1 were positively correlated(B=0.619, P<0.05).IGF-1 and sperm forward movement rate were positively correlated (B=0.150, P<0.05).Conclusions The level of IGF-1 in seminal plasma decrease in patients with normal body mass and infertility .The levels of ROS and IGF-1 rise in overweight and obese patients with infertility .The above indicators can help to analyze the infertility effect of overweight and obesity and provide reference for clinical treatment .
