CAJ | 학술논문

目的：观察黄芪桂枝五物汤加味对糖尿病周围神经病变（ DPN ）患者血管内皮生长因子（ VEGF）的影响。方法将60例DPN患者随机分为2组，对照组30例予基础疗法，治疗组30例在对照组治疗基础上应用黄芪桂枝五物汤加味治疗。2组均治疗12周。比较2组疗效，观察2组治疗前后腓总神经神经传导速度、VEGF变化。结果2组总有效率比较差异有统计学意义（ P＜0．05），治疗组疗效优于对照组。治疗组治疗后腓总神经传导速度、VEGF均较本组治疗前、对照组治疗后提高（ P＜0．05）。结论黄芪桂枝五物汤加味对DPN具有明显疗效，对神经传导速度、VEGF改善明显，无明显副作用。
목적：관찰황기계지오물탕가미대당뇨병주위신경병변（ DPN ）환자혈관내피생장인자（ VEGF）적영향。방법장60례DPN환자수궤분위2조，대조조30례여기출요법，치료조30례재대조조치료기출상응용황기계지오물탕가미치료。2조균치료12주。비교2조료효，관찰2조치료전후비총신경신경전도속도、VEGF변화。결과2조총유효솔비교차이유통계학의의（ P＜0．05），치료조료효우우대조조。치료조치료후비총신경전도속도、VEGF균교본조치료전、대조조치료후제고（ P＜0．05）。결론황기계지오물탕가미대DPN구유명현료효，대신경전도속도、VEGF개선명현，무명현부작용。
Objective To discuss the effect of Jiawei Huangqi Guizhi Wuwu Decoction on vascular endothe -lial growth factor in patients with diabetic peripheral neuropathy ( DPN) .Methods 60 DPN patients were randomly divided into two groups .30 cases in control group received basic therapy .30 cases in treatment group received Jiawei Huangqi Guizhi Wuwu Decoction on the basis of basic therapy .The course was twelve weeks in two groups .The clini-cal effect of two groups was compared ,the changes of nervus peroneus communis conduction velocity ,VEGF before and after treatment were observed in two groups .Results There was significant difference between two groups on the total effective rate (P<0.05).The effect in treatment group was superior to that in control group .Nervus peroneus communis conduction velocity after treatment in treatment group was raised compared with that before treatment in treatment group and after treatment in control group (P<0.05).VEGF concentration after treatment in treatment group was increased compared with that before treatment in treatment group and after treatment in control group ( P<0.05).Conclusion Jiawei Huangqi Guizhi Wuwu Decoction on DPN has obvious curative effect for the nerve con -duction velocity and VEGF ,no obvious side effects .