河北中医
河北中醫
하북중의
HEBEI JORNAL OF TRADITIONAL CHINESE MEDICINE
2015年
1期
18-21
,共4页
肝硬化%高血压,门静脉%并发症%中药疗法
肝硬化%高血壓,門靜脈%併髮癥%中藥療法
간경화%고혈압,문정맥%병발증%중약요법
Liver cirrhosis%Hypertension%Portal vein%Complication%Traditional Chinese medicine therapy
目的：观察泽芪汤对肝硬化门静脉高压症患者血流动力学和肝纤维化指标的影响。方法将60例肝硬化门静脉高压症患者随机分2组。2组均常规接受护肝、降酶等对症治疗，治疗组30例加服泽芪汤，对照组30例加服普萘洛尔。2组均治疗3个月后观察治疗前后肝纤维化指标透明质酸（ HA）、Ⅲ型前胶原（PCⅢ）、Ⅳ型胶原（Ⅳ－C）、层粘连蛋白（LN）变化，并检测门静脉内径（PVD）、脾静脉内径（SVD）、门静脉血流速度（Spv）及门静脉血流量（Qpv）。结果治疗组治疗后HA、PCⅢ、Ⅳ－C、LN均下降（P＜0．05），PVD、SVD、Spv及Qpv均改善（P＜0．05）；2组治疗后HA、PCⅢ、Ⅳ－C、LN、PVD、SVD、Spv及Qpv比较差异均有统计学意义（P＜0．05）。结论泽芪汤能较好地改善肝硬化门静脉高压，降低纤维化指标。
目的：觀察澤芪湯對肝硬化門靜脈高壓癥患者血流動力學和肝纖維化指標的影響。方法將60例肝硬化門靜脈高壓癥患者隨機分2組。2組均常規接受護肝、降酶等對癥治療，治療組30例加服澤芪湯，對照組30例加服普萘洛爾。2組均治療3箇月後觀察治療前後肝纖維化指標透明質痠（ HA）、Ⅲ型前膠原（PCⅢ）、Ⅳ型膠原（Ⅳ－C）、層粘連蛋白（LN）變化，併檢測門靜脈內徑（PVD）、脾靜脈內徑（SVD）、門靜脈血流速度（Spv）及門靜脈血流量（Qpv）。結果治療組治療後HA、PCⅢ、Ⅳ－C、LN均下降（P＜0．05），PVD、SVD、Spv及Qpv均改善（P＜0．05）；2組治療後HA、PCⅢ、Ⅳ－C、LN、PVD、SVD、Spv及Qpv比較差異均有統計學意義（P＜0．05）。結論澤芪湯能較好地改善肝硬化門靜脈高壓，降低纖維化指標。
목적：관찰택기탕대간경화문정맥고압증환자혈류동역학화간섬유화지표적영향。방법장60례간경화문정맥고압증환자수궤분2조。2조균상규접수호간、강매등대증치료，치료조30례가복택기탕，대조조30례가복보내락이。2조균치료3개월후관찰치료전후간섬유화지표투명질산（ HA）、Ⅲ형전효원（PCⅢ）、Ⅳ형효원（Ⅳ－C）、층점련단백（LN）변화，병검측문정맥내경（PVD）、비정맥내경（SVD）、문정맥혈류속도（Spv）급문정맥혈류량（Qpv）。결과치료조치료후HA、PCⅢ、Ⅳ－C、LN균하강（P＜0．05），PVD、SVD、Spv급Qpv균개선（P＜0．05）；2조치료후HA、PCⅢ、Ⅳ－C、LN、PVD、SVD、Spv급Qpv비교차이균유통계학의의（P＜0．05）。결론택기탕능교호지개선간경화문정맥고압，강저섬유화지표。
Objective To observe the effect of Zeqi decoction on hemodynamics and liver fibrosis indexes in liver cirrhosis patients with portal hypertension .Methods 60 cirrhotic patients with portal hypertension were ran-domly divided into treatment group and control group .Patients in two groups received conventional protecting liver ,re-ducing enzyme and other symptomatic treatment;the patients in the treatment group were added to Zeqi decoction ,pa-tients of the control group received oral propranolol .The course was three months in the two groups .Liver fibrosis markers hyaluronic acid (HA),procollagen type Ⅲ(PCⅢ),collagen type Ⅳ(Ⅳ-C),laminin (LN),and detect the diameters of the portal vein (PVD),splenic vein (SVD),portal vein flow velocity (Spv),portal venous blood flow (Qpv) were measured before and after treatment .Results After treatment,HA,PC Ⅲ,Ⅳ-C,LN were decreased in treatment group (P<0.05),portal vein diameter,blood flow velocity,blood flow before and after treatment were significantly different (P<0.05),compared with the control group after treatment also showed a significant difference (P<0.05).Conclusion Zeqi decoction can improve the liver cirrhosis with portal hypertension ,decrease the fibro-sis index.Curative effect is better than that of propranolol ,is an effective prescription in treating liver cirrhosis and portal hypertension .
