CAJ | 학술논문

目的：观察盐酸文拉法辛缓释胶囊联合重复经颅磁刺激（ rTMS）及丹栀逍遥丸在抑郁症治疗中的优势互补效应。方法将44例抑郁症患者随机分为2组，对照组21例予盐酸文拉法辛缓释胶囊联合rTMS治疗，治疗组23例在对照组治疗基础上加丹栀逍遥丸，连续治疗4周。分别于治疗前及治疗1、2、4周末进行汉密尔顿抑郁量表（ HAMD）评分评定，进行临床疗效评价，并采用 Asberg 抗抑郁药副反应量表（SERS）评估2组治疗过程中的副反应。结果治疗组总有效率（82．61％）高于对照组（66．67％，P＜0．05），治疗组临床疗效优于对照组；治疗组治疗2、4周末，HAMD评分低于本组治疗前及对照组同期（P＜0．05），治疗期间SERS评分低于对照组同期（ P＜0．05）。结论多模式联合治疗的方式在抗抑郁方面具有优势互补效应及减毒增效作用。
목적：관찰염산문랍법신완석효낭연합중복경로자자격（ rTMS）급단치소요환재억욱증치료중적우세호보효응。방법장44례억욱증환자수궤분위2조，대조조21례여염산문랍법신완석효낭연합rTMS치료，치료조23례재대조조치료기출상가단치소요환，련속치료4주。분별우치료전급치료1、2、4주말진행한밀이돈억욱량표（ HAMD）평분평정，진행림상료효평개，병채용 Asberg 항억욱약부반응량표（SERS）평고2조치료과정중적부반응。결과치료조총유효솔（82．61％）고우대조조（66．67％，P＜0．05），치료조림상료효우우대조조；치료조치료2、4주말，HAMD평분저우본조치료전급대조조동기（P＜0．05），치료기간SERS평분저우대조조동기（ P＜0．05）。결론다모식연합치료적방식재항억욱방면구유우세호보효응급감독증효작용。
Objective To observe the dominant complementation effects of multi -model ensemble in the treatment of patients with depression .Methods 44 depression patients were randomly divided into the treatment group (n=23) and the control group (n=21) and both groups were all treaded with Venlafaxine and rTMS .But the treatment groups were especially with Danzhixiaoyao pill additionally .The efficacy was evaluated by total score differ-ence of Hamilton Depression Scale.Adverse reaction was evaluated by rating scale for side effect ( SERS)R.esults The total effective rate in treatment group (82.61%) was higher than that of the control group (66.67%,P <0.05),HAMD 17-score in treatment group was lower than that in control group after 2 weeks of treatment (P<0.05).The side effects scales were lower than that in the control group (P<0.05).There was significant difference between the two groups in scores of HAMD total score difference and SERS (P<0.05).Conclusion The multi-model ensemble in treatment of patients with depression has the dominant complementation effects ,it worth application extension in clinical practice .