中国实用医药
中國實用醫藥
중국실용의약
CHINA PRACTICAL MEDICAL
2015年
1期
3-5
,共3页
2型糖尿病%冠状动脉硬化性心脏病%脂联素%网膜素%内脏脂肪素
2型糖尿病%冠狀動脈硬化性心髒病%脂聯素%網膜素%內髒脂肪素
2형당뇨병%관상동맥경화성심장병%지련소%망막소%내장지방소
Type 2 diabetes mellitus%Coronary heart disease%Adiponectin%Omentin%Visfatin
目的：探讨血清脂联素、网膜素、内脏脂肪素在2型糖尿病(T2DM)患者及冠状动脉硬化性心脏病(CHD)患者中的变化。方法健康体检者30例为对照组,2型糖尿病患者34例为T2DM组,冠状动脉硬化性心脏病患者41例为CHD组。采用双抗体夹心法酶联免疫吸附试验(ELISA)检测各组患者血清脂联素、网膜素和内脏脂肪素含量；采用全自动血生化分析仪分别检测各组患者空腹血清葡萄糖(FPG)、总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)和低密度脂蛋白胆固醇(LDL-C)含量,采用化学发光法检测各组患者空腹血清胰岛素(FINS)含量,采用稳态模型评估法(HOMA-IR)计算胰岛素抵抗指数。结果 T2DM组、CHD组血清脂联素、网膜素水平均明显低于对照组(F=34.99,100.65,q=7.60~21.68,P<0.01)；T2DM组、CHD组血清内脏脂肪素水平明显高于对照组(F=21.28,q=9.25,8.30,P<0.01), T2DM组与CHD组以上指标比较差异无统计学意义(P>0.05)。各组血清脂联素、网膜素、内脏脂肪素与HOMA-IR均有相关性(P<0.01)。结论血清脂联素、网膜素、内脏脂肪素与2型糖尿病、冠状动脉硬化性心脏病的发生发展密切相关。
目的：探討血清脂聯素、網膜素、內髒脂肪素在2型糖尿病(T2DM)患者及冠狀動脈硬化性心髒病(CHD)患者中的變化。方法健康體檢者30例為對照組,2型糖尿病患者34例為T2DM組,冠狀動脈硬化性心髒病患者41例為CHD組。採用雙抗體夾心法酶聯免疫吸附試驗(ELISA)檢測各組患者血清脂聯素、網膜素和內髒脂肪素含量；採用全自動血生化分析儀分彆檢測各組患者空腹血清葡萄糖(FPG)、總膽固醇(TC)、甘油三酯(TG)、高密度脂蛋白膽固醇(HDL-C)和低密度脂蛋白膽固醇(LDL-C)含量,採用化學髮光法檢測各組患者空腹血清胰島素(FINS)含量,採用穩態模型評估法(HOMA-IR)計算胰島素牴抗指數。結果 T2DM組、CHD組血清脂聯素、網膜素水平均明顯低于對照組(F=34.99,100.65,q=7.60~21.68,P<0.01)；T2DM組、CHD組血清內髒脂肪素水平明顯高于對照組(F=21.28,q=9.25,8.30,P<0.01), T2DM組與CHD組以上指標比較差異無統計學意義(P>0.05)。各組血清脂聯素、網膜素、內髒脂肪素與HOMA-IR均有相關性(P<0.01)。結論血清脂聯素、網膜素、內髒脂肪素與2型糖尿病、冠狀動脈硬化性心髒病的髮生髮展密切相關。
목적：탐토혈청지련소、망막소、내장지방소재2형당뇨병(T2DM)환자급관상동맥경화성심장병(CHD)환자중적변화。방법건강체검자30례위대조조,2형당뇨병환자34례위T2DM조,관상동맥경화성심장병환자41례위CHD조。채용쌍항체협심법매련면역흡부시험(ELISA)검측각조환자혈청지련소、망막소화내장지방소함량；채용전자동혈생화분석의분별검측각조환자공복혈청포도당(FPG)、총담고순(TC)、감유삼지(TG)、고밀도지단백담고순(HDL-C)화저밀도지단백담고순(LDL-C)함량,채용화학발광법검측각조환자공복혈청이도소(FINS)함량,채용은태모형평고법(HOMA-IR)계산이도소저항지수。결과 T2DM조、CHD조혈청지련소、망막소수평균명현저우대조조(F=34.99,100.65,q=7.60~21.68,P<0.01)；T2DM조、CHD조혈청내장지방소수평명현고우대조조(F=21.28,q=9.25,8.30,P<0.01), T2DM조여CHD조이상지표비교차이무통계학의의(P>0.05)。각조혈청지련소、망막소、내장지방소여HOMA-IR균유상관성(P<0.01)。결론혈청지련소、망막소、내장지방소여2형당뇨병、관상동맥경화성심장병적발생발전밀절상관。
Objective To investigate the level changes of serum adiponectin, omentin, and visfatin in patients with type 2 diabetes mellitus (T2DM) or coronary heart disease (CHD).Methods There were 30 health people as control group, 34 cases of type 2 diabetes mellitus as T2DM group, and 41 cases of coronary heart disease as CHD group. A double antibody sandwich enzyme-linked immunosorbent assay (ELISA) method was applied to detect the levels of serum adiponectin, omentin, and visfatin of the patients. Automatic blood biochemical analyzer was used for the detection of fasting serum glucose (FPG), total cholesterol (TC), triglycerides (TG), high density lipoprotein cholesterol (HDL-C) and low density lipoprotein cholesterol (LDL-C). Chemiluminescence was used to detect fasting serum insulin (FINS), and homeostasis model assessment of insulin resistance (HOMA-IR) was applied to assess the insulin resistance index.Results The levels of serum adiponectin and omentin of T2DM group and CHD group were significantly lower than that of the control group (F=34.99, 100.65,q=7.60~21.68, P<0.01). The levels of serum visfatin of T2DM group and CHD group were obviously higher than that of the control group (F=21.28,q=9.25, 8.30,P<0.01). The differences of indexes between T2DM group and CHD group were no statistically significant (P>0.05). The serum adiponectin, omentin, and visfatin in each group all had correlation with HOMA-IR (P<0.01).Conclusion Serum adiponectin, omentin and visfatin are closely correlated with the occurrence and development of T2DM and CHD.
