中国实用医药
中國實用醫藥
중국실용의약
CHINA PRACTICAL MEDICAL
2015年
2期
248-249
,共2页
非综合征性唇腭裂%转化生长因子%多态性
非綜閤徵性脣腭裂%轉化生長因子%多態性
비종합정성진악렬%전화생장인자%다태성
Non-syndromic cleft lip and palate%Transforming growth factor%Polymorphism
目的：探讨转化生长因子α基因rs11466285位点与东北地区非综合征性唇腭裂的发病关系。方法采用基因芯片检测166例患者(病例组)和150例正常志愿者(对照组)rs11466285的基因型，并进行χ2分析。结果基因型和等位基因在病例组与对照组中比较均有显著性差异(P<0.01)。结论中国东北人群转化生长因子α基因rs 11466285多态与非综合征性唇腭裂的发病密切相关。
目的：探討轉化生長因子α基因rs11466285位點與東北地區非綜閤徵性脣腭裂的髮病關繫。方法採用基因芯片檢測166例患者(病例組)和150例正常誌願者(對照組)rs11466285的基因型，併進行χ2分析。結果基因型和等位基因在病例組與對照組中比較均有顯著性差異(P<0.01)。結論中國東北人群轉化生長因子α基因rs 11466285多態與非綜閤徵性脣腭裂的髮病密切相關。
목적：탐토전화생장인자α기인rs11466285위점여동북지구비종합정성진악렬적발병관계。방법채용기인심편검측166례환자(병례조)화150례정상지원자(대조조)rs11466285적기인형，병진행χ2분석。결과기인형화등위기인재병례조여대조조중비교균유현저성차이(P<0.01)。결론중국동북인군전화생장인자α기인rs 11466285다태여비종합정성진악렬적발병밀절상관。
Objective To explore the relation between transforming growth factor α gene rs 11466285 and non-syndromic cleft lip and palate in Northeast China.Methods The detection by gene microarray was applied in showing the genotype of rs 11466285 in 166 patients (case group) and 150 healthy volunteers (control group). X2 analysis was also used in the detection.Results There was statistically significant difference of genotype and allele between patients and control group.Conclusion The relation between transforming growth factor α gene rs 11466285 and non-syndromic cleft lip and palate in Northeast China is closely correlated.
