CAJ | 학술논문

目的：探讨血清α-L-岩藻糖苷酶（AFU）、亮氨酸氨基肽酶（LAP）、r-谷氨酰转移酶（GGT）联合检测在早期原发性肝癌患者中的诊断价值。方法对85例肝病患者（肝硬化组45例、早期原发性肝癌组40例）及40例健康体检者（健康对照组）的血清 AFU、LAP 及 GGT 含量进行检测。结果早期原发性肝癌组、肝硬化组血清 AFU、GGT 的含量均高于健康对照组（均 P ＜0．05）。早期原发性肝癌组的 LAP 含量明显高于健康对照组，血清 AFU、LAP、GGT 单项检测及 AFU＋LAP＋GGT 联合检测阳性率均明显高于肝硬化组及健康体检组（均 P ＜0．05），其中 AFU＋LAP＋GGT 联合检测阳性率最高（92％）。肝硬化组与健康对照组 LAP 含量比较差异无统计学意义（P ＞0．05）。结论AFU＋LAP＋GGT 联合检测有利于原发性肝癌的早期诊断。
목적：탐토혈청α-L-암조당감매（AFU）、량안산안기태매（LAP）、r-곡안선전이매（GGT）연합검측재조기원발성간암환자중적진단개치。방법대85례간병환자（간경화조45례、조기원발성간암조40례）급40례건강체검자（건강대조조）적혈청 AFU、LAP 급 GGT 함량진행검측。결과조기원발성간암조、간경화조혈청 AFU、GGT 적함량균고우건강대조조（균 P ＜0．05）。조기원발성간암조적 LAP 함량명현고우건강대조조，혈청 AFU、LAP、GGT 단항검측급 AFU＋LAP＋GGT 연합검측양성솔균명현고우간경화조급건강체검조（균 P ＜0．05），기중 AFU＋LAP＋GGT 연합검측양성솔최고（92％）。간경화조여건강대조조 LAP 함량비교차이무통계학의의（P ＞0．05）。결론AFU＋LAP＋GGT 연합검측유리우원발성간암적조기진단。
ABSTRACT:Objective To investigate clinical value of combined detection of serum alpha-L-fu-cose glucosidase(AFU),leucine aminopeptidase(LAP)and r-glutamine transpeptidase(GGT)in the diagnosis of early-stage primary liver cancer.Methods Serum levels of AFU,LAP and GGT were detected in 45 patients with cirrhosis,40 patients with early-stage primary liver cancer and 40 healthy controls.Results Serum levels of AFU and GGT in early-stage primary liver cancer group or cirrhosis group were significantly higher than those in healthy control group(P <0.05). Serum levels of LAP in early-stage primary liver cancer group were significantly higher than those in healthy control group(P <0.05).No significant difference in LAP levels was found between early-stage primary liver cancer group and cirrhosis group(P >0.05).The positive rates of the de-tection of GGT,LAP and AFU alone or their combination in early-stage primary liver cancer group were significantly higher than those in cirrhosis group or healthy control group(P <0.05), in which that of their combination in early-stage primary liver cancer group was highest(92%). Conclusion The combined detection of GGT,LAP and AFU is conducive to the early diagnosis of primary liver cancer.