医学临床研究
醫學臨床研究
의학림상연구
JOURNAL OF CLINICAL RESEARCH
2014年
11期
2199-2202
,共4页
陈娜%谭秋荣%邓倩%李莉明%喻南慧
陳娜%譚鞦榮%鄧倩%李莉明%喻南慧
진나%담추영%산천%리리명%유남혜
革兰氏阴性菌%革兰氏阳性菌%真菌%抗感染药%抗药性,微生物%微生物敏感性试验%药物利用
革蘭氏陰性菌%革蘭氏暘性菌%真菌%抗感染藥%抗藥性,微生物%微生物敏感性試驗%藥物利用
혁란씨음성균%혁란씨양성균%진균%항감염약%항약성,미생물%미생물민감성시험%약물이용
Gram-Negative Bacteria%Gram-Positive Bacteria%Fungi%Anti-Infective Agents%Drug Resist-ance,Microbial%Microbial Sensitivity Tests%Drug Utilization
目的 了解2013年长沙市妇幼保健院临床分离菌株对常用抗菌药物的耐药性。方法 对本院2013年临床分离的1882株细菌采用K‐B法进行抗菌药物敏感试验，按美国临床实验室标准化协会（CLSI）2013年版判断结果。结果 临床分离菌株共1882株，其中革兰阳性菌557株（29．60％），革兰阴性菌803株（42．67％），真菌522株（27．73％）；革兰阳性菌中，耐甲氧西林金黄色葡萄球菌（M RSA ）的检出率为32．94％；未发现耐万古霉素和利奈唑胺的金黄色葡萄球菌；表皮葡萄球菌对苯唑西林的敏感性较高，耐药率仅为9．68％；粪肠球菌对氨苄西林较敏感，耐药率为6．25％；无乳链球菌对氨苄西林均无耐药性；革兰阴性菌中，未发现产超广谱β‐内酰胺酶（ESBLs）的大肠埃希菌和肺炎克雷伯菌；卡他莫拉菌对氨苄西林舒巴坦的敏感性高达100％；流感嗜血杆菌对氨苄西林和氨苄西林舒巴坦的耐药率均为8．51％。结论 对细菌耐药性进行定期监测有助于了解细菌耐药性的变迁，为临床合理用药提供理论依据。
目的 瞭解2013年長沙市婦幼保健院臨床分離菌株對常用抗菌藥物的耐藥性。方法 對本院2013年臨床分離的1882株細菌採用K‐B法進行抗菌藥物敏感試驗，按美國臨床實驗室標準化協會（CLSI）2013年版判斷結果。結果 臨床分離菌株共1882株，其中革蘭暘性菌557株（29．60％），革蘭陰性菌803株（42．67％），真菌522株（27．73％）；革蘭暘性菌中，耐甲氧西林金黃色葡萄毬菌（M RSA ）的檢齣率為32．94％；未髮現耐萬古黴素和利奈唑胺的金黃色葡萄毬菌；錶皮葡萄毬菌對苯唑西林的敏感性較高，耐藥率僅為9．68％；糞腸毬菌對氨芐西林較敏感，耐藥率為6．25％；無乳鏈毬菌對氨芐西林均無耐藥性；革蘭陰性菌中，未髮現產超廣譜β‐內酰胺酶（ESBLs）的大腸埃希菌和肺炎剋雷伯菌；卡他莫拉菌對氨芐西林舒巴坦的敏感性高達100％；流感嗜血桿菌對氨芐西林和氨芐西林舒巴坦的耐藥率均為8．51％。結論 對細菌耐藥性進行定期鑑測有助于瞭解細菌耐藥性的變遷，為臨床閤理用藥提供理論依據。
목적 료해2013년장사시부유보건원림상분리균주대상용항균약물적내약성。방법 대본원2013년림상분리적1882주세균채용K‐B법진행항균약물민감시험，안미국림상실험실표준화협회（CLSI）2013년판판단결과。결과 림상분리균주공1882주，기중혁란양성균557주（29．60％），혁란음성균803주（42．67％），진균522주（27．73％）；혁란양성균중，내갑양서림금황색포도구균（M RSA ）적검출솔위32．94％；미발현내만고매소화리내서알적금황색포도구균；표피포도구균대분서서림적민감성교고，내약솔부위9．68％；분장구균대안변서림교민감，내약솔위6．25％；무유련구균대안변서림균무내약성；혁란음성균중，미발현산초엄보β‐내선알매（ESBLs）적대장애희균화폐염극뢰백균；잡타막랍균대안변서림서파탄적민감성고체100％；류감기혈간균대안변서림화안변서림서파탄적내약솔균위8．51％。결론 대세균내약성진행정기감측유조우료해세균내약성적변천，위림상합리용약제공이론의거。
Objective] To understand the resistance of clinical isolates obtained from Changsha maternal and child health hospital in 2013 to commonly used antimicrobial agents .[Methods]Kirby‐Bauer(K‐B) method was used for anti‐bacterial drug susceptibility test of 1882 stains of bacteria isolated from our hospital in 2013 .According to 2013 national committee for clinical and laboratory standards institute(CLSI) ,the results were analyzed .[Results] A total of 1882 pathogenic strains were clinically isolated and included 557 Gram‐positive bacteria(29 .60% ) ,803 Gram‐negative bacteria (42 .67% ) and 522 fungi(27 .73% ) .Among Gram‐positive bacteria ,the detection rate of methicillin resistant staphylo‐coccus aureus(MASA) was 32 .94% ,and vancomycin and linezolid‐resistant staphylococcus aureus were not found ,and the sensitivity of staphylococcus epidermidis to oxacillin was high(90 .32% ) ,and the Enterococcus faecalis was sensitive to ampicillin and the resistant rate was 6 .25% ,and the sensitivity of Streptococcus agalactiae to ampicillin was 100% .A‐mong Gram‐negative bacteria ,Escherichia coli and Klebsiella pneumonia producing the extended spectrum beta‐lactamases (ESBLs) were not found ,and the sensitivity of Moraxelle catarrhalis to Ampicillin and Sulbactam was 100% ,and the re‐sistance rate of Haemophilus influenzae to Ampicillin and Sulbactam was 8 .51% .[Conclusion] Regular surveillance of bacterial drug resistance is helpful to understand the transition of bacterial drug resistance and can provide a theoretical ba‐sis for rational administration .
