医学临床研究
醫學臨床研究
의학림상연구
JOURNAL OF CLINICAL RESEARCH
2014年
11期
2186-2188
,共3页
腺病毒,人%重症肺炎%免疫功能%儿童
腺病毒,人%重癥肺炎%免疫功能%兒童
선병독,인%중증폐염%면역공능%인동
Adenovirus,Human%Severe Pneumonia%Immune Function%Children
目的 了解重症腺病毒肺炎（ADVP）患儿临床特点及免疫功能情况。方法 回顾性分析2013年1月至2013年12月期间101例重症 ADVP患儿和122例非重症 ADVP患儿临床特点及免疫相关指标资料。结果 重症ADVP患儿男性多于女性，冬春季节易发；重症组与非重症组ADVP患儿住院天数、中性粒细胞、C反应蛋白和降钙素原比较，差异有统计学意义（ P ＜0．05）。重症组患儿CD3、CD4降低构成比分别高于非重症组，两者之间的差异有统计学意义（ P ＜0．05） ，而重症组CD8升高构成比低于非重症组，两者之间的差异有统计学意义（ P ＜0．05）。结论 重症ADVP患儿体内存在较强的炎症过程，免疫应答性降低，免疫功能紊乱，临床上应加强相关指标早期检测，并尽早给予干预和综合治疗，控制病情进展。
目的 瞭解重癥腺病毒肺炎（ADVP）患兒臨床特點及免疫功能情況。方法 迴顧性分析2013年1月至2013年12月期間101例重癥 ADVP患兒和122例非重癥 ADVP患兒臨床特點及免疫相關指標資料。結果 重癥ADVP患兒男性多于女性，鼕春季節易髮；重癥組與非重癥組ADVP患兒住院天數、中性粒細胞、C反應蛋白和降鈣素原比較，差異有統計學意義（ P ＜0．05）。重癥組患兒CD3、CD4降低構成比分彆高于非重癥組，兩者之間的差異有統計學意義（ P ＜0．05） ，而重癥組CD8升高構成比低于非重癥組，兩者之間的差異有統計學意義（ P ＜0．05）。結論 重癥ADVP患兒體內存在較彊的炎癥過程，免疫應答性降低，免疫功能紊亂，臨床上應加彊相關指標早期檢測，併儘早給予榦預和綜閤治療，控製病情進展。
목적 료해중증선병독폐염（ADVP）환인림상특점급면역공능정황。방법 회고성분석2013년1월지2013년12월기간101례중증 ADVP환인화122례비중증 ADVP환인림상특점급면역상관지표자료。결과 중증ADVP환인남성다우녀성，동춘계절역발；중증조여비중증조ADVP환인주원천수、중성립세포、C반응단백화강개소원비교，차이유통계학의의（ P ＜0．05）。중증조환인CD3、CD4강저구성비분별고우비중증조，량자지간적차이유통계학의의（ P ＜0．05） ，이중증조CD8승고구성비저우비중증조，량자지간적차이유통계학의의（ P ＜0．05）。결론 중증ADVP환인체내존재교강적염증과정，면역응답성강저，면역공능문란，림상상응가강상관지표조기검측，병진조급여간예화종합치료，공제병정진전。
Objective] To understand clinical characteristics and T lymphocyte subsets of severe adenovirus(ADV) pneumonia in children .[Methods]Clinical characteristics and immune‐related indicators of 101 pediatric patients with se‐vere ADV pneumonia and 122 pediatric patients with non‐severe ADV pneumonia from Jan .2013 to Dec .2013 were ana‐lyzed retrospectively .[Results] Among pediatric patients with severe ADV pneumonia ,male patients were more than fe‐male patients .Severe ADV pneumonia mainly occurred in winter and spring .There were significant differences in hospital day ,neutrophil ,c‐reactive protein(CRP) and procalcitonin(PCT) between severe ADV pneumonia group and non‐severe ADV pneumonia group( P<0 .05) .The constituent ratios of the decreasing of CD3 and CD4 in pediatric patients with severe ADV pneumonia were higher than those in pediatric patients with non‐severe ADV pneumonia ,and there was sig‐nificant difference( P<0 .05) .The constituent ratio of the increasing of CD8 in severe ADV pneumonia group was lower than that in non‐severe ADV pneumonia group ,and there was significant difference( P <0 .05) .[Conclusion]Pediatric patients with severe adenovirus pneumonia have strong inflammatory process ,the decreased immunologic responsiveness and immunity function disturbance .Early detection of the correlative indicators should be strengthened in clinical practice . Intervention and comprehensive treatment should be given to control the development of the disease .
