CAJ | 학술논문

目的：探讨大脑中动脉狭窄（MCAS）与轻度认知功能损障碍（MCI）的相关性及他汀类药物改善MCI的临床疗效。方法：连续选取在本院行经颅多普勒彩色超声（TCD）检查的住院或门诊患者636例，以简易精神状态检查量表（MMSE）和临床痴呆评定量表（CDR）作为认知功能评价指标，筛查 MCI 者158例，其中MCI并MCAS者44例及MCI不并MCAS者58例为治疗组，在常规及高血压、糖尿病等基础疾病治疗基础上，口服阿托伐他汀钙20 mg／d；选取MCI不并MCAS 者56例为对照组，1年后复测MMSE 评分。结果：124例 MCAS 患者中有 MCI 者44例，患病率为35．5％，512例非 MCAS 患者中为 MCI 者114例，患病率为22．3％，两组患病率比较差异有统计学意义。治疗后阿托伐他丁治疗组中 MCI 并 MCAS 患者及 MCI 不并MCAS患者的MMSE得分较治疗前有改善，差异有统计学意义，且MCAS合并MCI组改善更为明显。结论：MCAS与MCI的发生有关，阿托伐他汀钙能改善MCI患者近期记忆力，对合并MCAS 引起的MCI患者疗效更显著。
목적：탐토대뇌중동맥협착（MCAS）여경도인지공능손장애（MCI）적상관성급타정류약물개선MCI적림상료효。방법：련속선취재본원행경로다보륵채색초성（TCD）검사적주원혹문진환자636례，이간역정신상태검사량표（MMSE）화림상치태평정량표（CDR）작위인지공능평개지표，사사 MCI 자158례，기중MCI병MCAS자44례급MCI불병MCAS자58례위치료조，재상규급고혈압、당뇨병등기출질병치료기출상，구복아탁벌타정개20 mg／d；선취MCI불병MCAS 자56례위대조조，1년후복측MMSE 평분。결과：124례 MCAS 환자중유 MCI 자44례，환병솔위35．5％，512례비 MCAS 환자중위 MCI 자114례，환병솔위22．3％，량조환병솔비교차이유통계학의의。치료후아탁벌타정치료조중 MCI 병 MCAS 환자급 MCI 불병MCAS환자적MMSE득분교치료전유개선，차이유통계학의의，차MCAS합병MCI조개선경위명현。결론：MCAS여MCI적발생유관，아탁벌타정개능개선MCI환자근기기억력，대합병MCAS 인기적MCI환자료효경현저。
Objective To investigate the correlation of the middle cerebral artery stenosis (MCAS) and the mild cognitive function impairment (MCI),and the clinical efficacy of statins in patients with MCI. Methods Six hundred and thirty-six patientse,who received transcranial color doppler ultrasound (TCD)assay, were enrolled in our hospital hospitalization or outpatients. The simple mental state examination (MMSE) and clinical dementia rating scale (CDR) were used as cognitive function assessment indexes. Forty-four cases of MCI with MCAS and 58 cases of MCI with NMCAS were used as the treatment group , who received the atorvastatin 20 mg every day , 56 cases of MCI with NMCAS were used as the control group , who only received the routine and basic diseases treatment. One yearlater,we determined the changes of MMSE and CDRagain. Results We detected 124 patients with MCAS, 512 patients with NMCAS, and 44 cases of MCAS patients with MCI, the prevalence was 35.5%,114 cases of NMCAS in patients with MCI, with the prevalence of 22.3%, the prevalence between the two groups was statistically different. One year later, the patients in the treatment group, MMSE score was improved, the score of MCI of the MCAS group improved more significantly. Conclusion The middle cerebral artery stenosis correlated with the occurrence of MCI. Atorvastatin could improve cognitive function in patients with MCI, especially for MCI which was caused by middle cerebral artery stenosis.