CAJ | 학술논문

目的：观察瑞舒托伐他汀对血脂正常高血压患者脉搏波传导速度（ PWV）、踝臂指数（ ABI）及血管内皮功能的影响。方法选择南京医科大学附属淮安第一医院2011年1月～2012年6月心内科门诊及住院的78例血脂正常高血压患者，随机分成瑞舒伐他汀组39例和对照组39例。瑞舒伐他汀组在服用常规降压药物的基础上，每晚睡前服用瑞舒伐他汀10mg，对照组仅服用常规降压药物，共随访6个月。观察治疗前后两组PWV、ABI、血浆一氧化氮、内皮素－1和高敏C反应蛋白（ hs－CRP）的变化。结果两组治疗前后收缩压和舒张压的差值相比无统计学意义（ P＞0．05）。瑞舒伐他汀组治疗后PWV、内皮素－1、hs－CRP较治疗前分别降低－4．1±0．5，－17．4±2．5，－2．8±0．2，与对照组（－0．6±0．4，－3．3±0．5，－0．2±0．1）相比，差异有统计学意义（P＜0．05）；ABI、一氧化氮较治疗前分别升高0．21±0．04，19．9±3．6，与对照组（0．02±0．01，2．0±0．8）相比，差异有统计学意义（P＜0．05）。对照组治疗后PWV、ABI、内皮素－1、一氧化氮、hs－CRP与治疗前相比，差异无统计学意义（ P＞0．05）。结论瑞舒托伐他汀可以通过改善血管内皮细胞功能和抑制炎症来改善血管的弹性，以保护血脂正常高血压患者的血管功能。
목적：관찰서서탁벌타정대혈지정상고혈압환자맥박파전도속도（ PWV）、과비지수（ ABI）급혈관내피공능적영향。방법선택남경의과대학부속회안제일의원2011년1월～2012년6월심내과문진급주원적78례혈지정상고혈압환자，수궤분성서서벌타정조39례화대조조39례。서서벌타정조재복용상규강압약물적기출상，매만수전복용서서벌타정10mg，대조조부복용상규강압약물，공수방6개월。관찰치료전후량조PWV、ABI、혈장일양화담、내피소－1화고민C반응단백（ hs－CRP）적변화。결과량조치료전후수축압화서장압적차치상비무통계학의의（ P＞0．05）。서서벌타정조치료후PWV、내피소－1、hs－CRP교치료전분별강저－4．1±0．5，－17．4±2．5，－2．8±0．2，여대조조（－0．6±0．4，－3．3±0．5，－0．2±0．1）상비，차이유통계학의의（P＜0．05）；ABI、일양화담교치료전분별승고0．21±0．04，19．9±3．6，여대조조（0．02±0．01，2．0±0．8）상비，차이유통계학의의（P＜0．05）。대조조치료후PWV、ABI、내피소－1、일양화담、hs－CRP여치료전상비，차이무통계학의의（ P＞0．05）。결론서서탁벌타정가이통과개선혈관내피세포공능화억제염증래개선혈관적탄성，이보호혈지정상고혈압환자적혈관공능。
Objectives To investigate the effect of Rosuvastatin on pulse wave velocity( PWV) ,ankle-brachial index( ABI) and endothelial function in essential hypertension patients with normal blood lipid.Methods 78 essential hypertension patients with nor-mal blood lipid in Huaian first hospital affiliated to Nanjing medical university between January 2011 and June 2012 were divided in-to Rosuvastatin group and control group,Rosuvastatin group were given antihypertensive drug and Rosuvastatin 10mg before bedtime while control group were given antihypertensive drug.PWV,ABI,nitric oxide (NO),endothelin-1(ET-l) and high sensitivity C-re-active protein ( hs-CRP) were measured before and after treatment of 6 months.Results By the end of six months therapy,no sig-nificant difference in blood pressure was observed between two groups.PWV,ET-l and hs-CRP were significantly decreased in rosuv-astatin group(-4.1 ±0.5,-17.4 ±2.5,-2.8 ±0.2)compared with control group( -0.6 ±0.4,-3.3 ±0.5,-0.2 ±0.1)(P<0.05),ABI and NO were significantly increased in rosuvastatin group(0.21 ±0.04,19.9 ±3.6) compared with control group (0.02 ±0.01,2.0 ±0.8)(P<0.05).There were no significant difference in PWV,ABI, ET-l, NO and hs-CRP in control group after treatment as compared with baseline ( P>0.05 ) .Conclusion Rosuvastatin can exert beneficial effect on arterial elasticity through improving endothelial function and inhibiniting inflamation reaction in essential hypertension patients with normal blood lipid.