CAJ | 학술논문

以3,5_二氟苯腈为起始原料与乙基溴化镁反应合成的3,5_二氟苯丙酮,经过溴代、胺化、环合、酸化反应,合成4个间二氟吗啉醇盐酸盐化合物,目标化合物的结构经1 H NMR,IR和MS分析确证,利用小鼠强迫游泳抗抑郁药理模型对所合成的化合物进行抗抑郁药理活性试验。结果表明,目标化合物Ⅵ4具有一定的抗抑郁活性。
이3,5_이불분정위기시원료여을기추화미반응합성적3,5_이불분병동,경과추대、알화、배합、산화반응,합성4개간이불마람순염산염화합물,목표화합물적결구경1 H NMR,IR화MS분석학증,이용소서강박유영항억욱약리모형대소합성적화합물진행항억욱약리활성시험。결과표명,목표화합물Ⅵ4구유일정적항억욱활성。
In this paper,3,5_difluoropropiophenone is synthetised using 3,5_difluorine ben_zene nitriles as the raw material reaction with ethyl magnesium bromide. Starting from 3,5_difluoropropiophenone,the four m_difluorine morpholinol hydrochloride are synthetised via several steps including bromination, amination, cyclization and acidification. Using the forced swim mice model of antidepressant pharmacology,the pharmacological effects of an_tidepressant of the synthesized compounds were observed. The target compound is synthe_tised and its structure is proved by 1 H NMR,IR and MS. Results show that compound Ⅵ4 have potent antidepressant activities.