CAJ | 학술논문

水痘‐带状疱疹病毒（VZV）属疱疹病毒α亚科，即人类疱疹病毒3型，为双链DNA病毒。原发感染可引起具有高度传染性的全球流行性疾病———水痘；潜伏病毒的再激活感染可引发典型的疼痛性皮肤病———带状疱疹及不典型的内脏器官感染。日本和美国分别自1987年和1995年开始实行给全体儿童预防接种水痘减毒活疫苗（vOka）后，两国儿童的水痘发病率和病死率显著降低。但VZV疫苗的不良反应，包括二次传播和突破感染等时有发生，因此有必要研发更为有效、安全的新型疫苗。本文就 VZV相关疫苗的有效性、安全性及其新型疫苗的研究进展进行综述。
수두‐대상포진병독（VZV）속포진병독α아과，즉인류포진병독3형，위쌍련DNA병독。원발감염가인기구유고도전염성적전구류행성질병———수두；잠복병독적재격활감염가인발전형적동통성피부병———대상포진급불전형적내장기관감염。일본화미국분별자1987년화1995년개시실행급전체인동예방접충수두감독활역묘（vOka）후，량국인동적수두발병솔화병사솔현저강저。단VZV역묘적불량반응，포괄이차전파화돌파감염등시유발생，인차유필요연발경위유효、안전적신형역묘。본문취 VZV상관역묘적유효성、안전성급기신형역묘적연구진전진행종술。
Varicella‐zoster virus (VZV) ,or human herpes virus type 3 ,is a member of the Herpesviridae family .VZV causes varicella (chickenpox) as primary infection which is a highly contagious epidemic disease globally .VZV reactivation from latency results in herpes zoster (shingle ) which is a painful skin disease .Japan and the United States started to vaccinate all children in 1987 and 1995 respectively ,which has reduced varicella‐related morbidity and mortality significantly . However , adverse events following administration of vaccine occur occasionally including secondary transmission and breakthrough infections . The research for safer VZV vaccine has been progressing with foreseeable advances .