CAJ | 학술논문

金属β‐内酰胺酶（MBL ）可广泛水解多种抗生素，对常规β‐内酰胺酶抑制剂如克拉维酸、舒巴坦等不敏感。产MBL肠杆菌科细菌一直是临床公认的多重耐药病原体。尤其是在发现新德里金属β‐内酰胺酶后，人们更加重视肠杆菌科细菌中检出 MBL的情况，因为其所致感染日渐严重。因此，快速、准确检测出产MBL菌株是有效预防、控制感染发生与播散的重要环节。本文就肠杆菌科细菌MBL的发现及分类、耐药基因传播、检测方法等进行简要概述。
금속β‐내선알매（MBL ）가엄범수해다충항생소，대상규β‐내선알매억제제여극랍유산、서파탄등불민감。산MBL장간균과세균일직시림상공인적다중내약병원체。우기시재발현신덕리금속β‐내선알매후，인문경가중시장간균과세균중검출 MBL적정황，인위기소치감염일점엄중。인차，쾌속、준학검측출산MBL균주시유효예방、공제감염발생여파산적중요배절。본문취장간균과세균MBL적발현급분류、내약기인전파、검측방법등진행간요개술。
Metallo‐β‐lactamase ( MBL ) can hydrolyze a variety of antibiotics , and is insensitive to conventionalβ‐lactamase inhibitors ,such as clavulanic acid and sulbactam .After the reporting of New Delhi metallo‐β‐lactamase (NDM) ,Enterobacteriaceae producing MBL have been recognized as clinical multidrug‐resistant pathogens ,and the infections caused by them in clinic are becoming increasingly serious .Rapid and accurate detection of this group of strains is an important link to prevent and control the occurrence and spread of infection effectively .The research progress on MBL produced by Enterobacteriaceae covering its discovery ,classification ,spreading and detection methods is reviewed in the present paper .