CAJ | 학술논문

为探讨蝙蝠葛酚性碱（ PAMD）抗胃癌的作用机理，通过实时定量PCR观察PAMD对胃癌细胞株SGC－7901 COX－2 mRNA表达的影响．结果表明，PAMD各剂量组均能下调 COX－2 mRNA的表达，其中PAMD（20）剂量组下调COX－2的作用有统计学差异，且优于阳性对照组．PAMD抗胃癌的作用机理可能与其抑制COX－2基因表达有关．
위탐토편복갈분성감（ PAMD）항위암적작용궤리，통과실시정량PCR관찰PAMD대위암세포주SGC－7901 COX－2 mRNA표체적영향．결과표명，PAMD각제량조균능하조 COX－2 mRNA적표체，기중PAMD（20）제량조하조COX－2적작용유통계학차이，차우우양성대조조．PAMD항위암적작용궤리가능여기억제COX－2기인표체유관．
To study inhibition mechanism of gastric cancer of Phenolic alkaloids from Meni-sphermum dauricum ( PAMD) the effect PAMD on mRNA expression of COX-2 of human gastric cancer cell SGC-7901 was observed by Real-time PCR.The results indicated that PAMD groups were able to cut the mRNA expression of COX-2 , and PAMD ( 20 ) group significantly reduced the COX-2 and better than the positive control.The mechanism may be related to its inhibition of COX-2 gene expression.