CAJ | 학술논문

αB晶状体蛋白是脊椎动物晶状体的结构性蛋白，广泛表达于非晶状体组织中。αB晶状体蛋白作为热休克蛋白家族成员之一，具有分子伴侣和抗细胞凋亡等生物学功能。多种因素引起的损伤，如视网膜病变、炎症反应性疾病和神经系统疾病等都与αB晶状体蛋白存在密切关系。本文综述了αB晶状体蛋白在视网膜及眼外组织器官中表达及其作用机制的研究进展。
αB정상체단백시척추동물정상체적결구성단백，엄범표체우비정상체조직중。αB정상체단백작위열휴극단백가족성원지일，구유분자반려화항세포조망등생물학공능。다충인소인기적손상，여시망막병변、염증반응성질병화신경계통질병등도여αB정상체단백존재밀절관계。본문종술료αB정상체단백재시망막급안외조직기관중표체급기작용궤제적연구진전。
αB-crystallin is the structural protein of vertebrate lens, w hich is w idely expressed in non-lens tissue. As one of the heat shock protein fam ily m em bers,αB-crystallin possesses biological proper-ties of m olecular chaperones and anti-apoptotic effects. Multi-factor injuries, such as retinopathy, inflam-m ation and nervous system diseases, have a closely relationship w ith αB-crystallin. T his paper review s the research progress of the expression and m echanism ofαB-crystallin in retina and extraocular tissues and organs.