CAJ | 학술논문

利用2-吡啶甲醛、N，N?二甲基乙二胺制备了一种新的席夫碱铜配合物，并通过X?射线单晶衍射、元素分析和ESI?MS对其结构进行分析?晶体结构分析表明，配合物呈现扭曲的四方锥构型?用紫外?可见吸收光谱、荧光光谱和圆二色光谱研究了配合物与小牛胸腺DNA（ CT?DNA）和人血清白蛋白（ HSA）的结合性质?结果表明：配合物以插入的方式与DNA相互作用，且配合物与HSA的相互作用为静态猝灭机制，分子间作用力为氢键和范德华力?
이용2-필정갑철、N，N?이갑기을이알제비료일충신적석부감동배합물，병통과X?사선단정연사、원소분석화ESI?MS대기결구진행분석?정체결구분석표명，배합물정현뉴곡적사방추구형?용자외?가견흡수광보、형광광보화원이색광보연구료배합물여소우흉선DNA（ CT?DNA）화인혈청백단백（ HSA）적결합성질?결과표명：배합물이삽입적방식여DNA상호작용，차배합물여HSA적상호작용위정태졸멸궤제，분자간작용력위경건화범덕화력?
A novel copper( II)complex was prepared by pyridine?2?aldehyde and N,N?dimethylethylenediamine,and characterized by single?crystal X?ray diffraction,elemental analysis,and ESI?MS? Single?crystal analysis revealed that the complex shows a distorted pseudo?square?pyramidal geometry? The binding properties of the complex with calf thymus DNA( CT?DNA)and HSA were investiga?ted by UV?visible( UV?vis),uorescence and circular dichroism( CD)spectra? The complex binds signicantly to CT?DNA by intercala?tion modes,and the complex binding to protein HSA belongs to static quenching mechanism? The interaction between the complex and HSA involve hydrogen bonding and weak van der Waals?