CAJ | 학술논문

目的：观察氯雷他定联合四物消风饮治疗慢性荨麻疹的临床疗效并对IgE、白介素水平进行研究。方法：选取慢性荨麻疹患者106例，随机分为对照组和治疗组，各53例。对照组口服氯雷他定治疗，治疗组口服氯雷他定联合四物消风饮治疗，4周后比较两组治疗的临床效果。同时采用联免疫吸附法（ ELISA）分别检测正常组和治疗组患者治疗前后血清中的IgE和IL－2、IL－4和IL－10的水平。结果：4周治疗后，对照组的总有效率为66．04％，治疗组的有效率为94．34％，治疗组有效率显著高于对照组（ P＜0．05）。与正常组相比，经氯雷他定和四物消风饮联合治疗后，治疗前IgE、IL－4和IL－10水平显著升高，IL－2水平降低；治疗后IgE、IL－4和IL－10水平显著降低，IL－2水平显著升高。结论：氯雷他定和四物消风饮联合用药治疗慢性荨麻疹具有良好的疗效，其作用机制可能与调节IgE、IL－2、IL－4和IL－10的水平有关。
목적：관찰록뢰타정연합사물소풍음치료만성담마진적림상료효병대IgE、백개소수평진행연구。방법：선취만성담마진환자106례，수궤분위대조조화치료조，각53례。대조조구복록뢰타정치료，치료조구복록뢰타정연합사물소풍음치료，4주후비교량조치료적림상효과。동시채용련면역흡부법（ ELISA）분별검측정상조화치료조환자치료전후혈청중적IgE화IL－2、IL－4화IL－10적수평。결과：4주치료후，대조조적총유효솔위66．04％，치료조적유효솔위94．34％，치료조유효솔현저고우대조조（ P＜0．05）。여정상조상비，경록뢰타정화사물소풍음연합치료후，치료전IgE、IL－4화IL－10수평현저승고，IL－2수평강저；치료후IgE、IL－4화IL－10수평현저강저，IL－2수평현저승고。결론：록뢰타정화사물소풍음연합용약치료만성담마진구유량호적료효，기작용궤제가능여조절IgE、IL－2、IL－4화IL－10적수평유관。
Objective:To study the clinical effect of Loratadine and Si Wu Xiao Feng Yin on chronic urticaria and related influence on IgE and interleukins.Methods:106 patients with chronic urticaria were divided into two groups at random, 53 cases in each group.The control group was treated with Loratadine and the treatment group was with Loratadine and Si Wu Xiao Feng Yin.After 4 weeks'treatment, the effects of two groups were compared.ELISA method was applied to detect the levels of IgE, IL-2, IL-4 and IL-10 in patients'serum in normal group and treatment group.Results:Af-ter treatment of 4 weeks,the total effective rate in the control group was 66.04%, and the total effective rate in the treat-ment group was 94.34%.The total effective rate in the treatment group was higher than that in the normal group( P<0.05).Compared with the normal group, levels of IgE, IL-4 and IL-10 in patients'serum were increased and level of IL-2 was decreased with the pre-treatment of Loratadine and Si Wu Xiao Feng Yin .After treatment by Loratadine and Si Wu Xiao Feng Yin, IL-2 level was increased, and levels of IgE, IL-4 and IL-10 were decreased.Conclusion:Loratadine with Si Wu Xiao Feng Yin has a distinct effect on treating chronic urticaria, which can be related to regula-ting the levels of IgE, IL-2, IL-4 and IL-10.