CAJ | 학술논문

目的：探讨交通心肾法中药对老龄雌鼠下丘脑－垂体－卵巢雌激素受体（ estrogen receptor，ER）的影响。方法：选用15月龄雌性SD大鼠，将其分为空白组、中药治疗组、西药对照组和中药对照组，分别给予生理盐水、宁更丹、戊酸雌二醇和更年安灌胃，另选3月龄大鼠作为青年对照组，采用酶免法检测大鼠下丘脑、垂体、卵巢ER。结果：与空白组相比，中药治疗组下丘脑、垂体和卵巢的雌激素受体含量均明显升高，有显著性差异（P＜0．05）。中药对照组和西药对照组仅能升高下丘脑的ER，有显著性差异（ P＜0．05）。结论：交通心肾法中药能升高下丘脑、垂体和卵巢的雌激素受体含量，可能是其治疗更年期综合征的作用机制之一。
목적：탐토교통심신법중약대노령자서하구뇌－수체－란소자격소수체（ estrogen receptor，ER）적영향。방법：선용15월령자성SD대서，장기분위공백조、중약치료조、서약대조조화중약대조조，분별급여생리염수、저경단、무산자이순화경년안관위，령선3월령대서작위청년대조조，채용매면법검측대서하구뇌、수체、란소ER。결과：여공백조상비，중약치료조하구뇌、수체화란소적자격소수체함량균명현승고，유현저성차이（P＜0．05）。중약대조조화서약대조조부능승고하구뇌적ER，유현저성차이（ P＜0．05）。결론：교통심신법중약능승고하구뇌、수체화란소적자격소수체함량，가능시기치료경년기종합정적작용궤제지일。
Objective:To study the effect of herbs of Jiaotong Xinshen therapy on hypothalamus-pituitary-ovarian ER in old female rats.Methods:Choose female SD rats aged 15 months, and they were divided into blank group, Chinese med-icine treatment group, western medicine control group, Chinese medicine control group.They were given normal saline, Ning Gengdan, progynova and Gengnian'an gavage treatment, and choose three-month old rats as the young control group.Elisa method was used to measure the levels of hypothalamus , pituitary and ovarian ER.Results:Compared with the blank group,the hypothalamus, pituitary and ovarian estrogen receptor levels in Chinese medicine treatment group were significantly elevated, and there were significant differences ( P <0.05 ) .Traditional Chinese medicine control group and western medicine control group could only increase the hypothalamus ER, and there were significant differ-ences ( P<0.05) .Conclusion:The therapy of Jiaotong Xinshen can increase the hypothalamus, pituitary and ovarian ER levels,which may be one of the mechanism in the treatment of menopausal syndrome.