CAJ | 학술논문

通过单因素试验,确定对目标产物产率影响最显著的3个因素分别为羟基香茅醛与1,2-丙二醇物质的量比、反应温度和反应时间。根据Central Composite Design试验设计原理,采用3因素3水平的响应面法,以目标产物产率为响应值,分析各个因素的显著性和交互作用,结果表明最佳合成条件为羟基香茅醛与1,2-丙二醇物质的量比为1∶3.5,反应温度为38℃,反应时间4.4 h,羟基香茅醛与甲苯物质的量比1∶2~1∶2.5,此条件下目标产物产率为89.76%。
통과단인소시험,학정대목표산물산솔영향최현저적3개인소분별위간기향모철여1,2-병이순물질적량비、반응온도화반응시간。근거Central Composite Design시험설계원리,채용3인소3수평적향응면법,이목표산물산솔위향응치,분석각개인소적현저성화교호작용,결과표명최가합성조건위간기향모철여1,2-병이순물질적량비위1∶3.5,반응온도위38℃,반응시간4.4 h,간기향모철여갑분물질적량비1∶2~1∶2.5,차조건하목표산물산솔위89.76%。
On the basis of single factor experiments, the synthesis conditions of hydroxyl citronella aldehyde-1,2-propanediol acetal from hydroxycitronellal and 1,2-propylene glycol were optimized using response surface method (RSM). The results of the single factor experiments showed that the most significant factors were the substance ratio of hydroxycitronellal to 1,2-propylene glycol, the reaction temperature and the reaction time. According to the experiment design principle of Central Composite Design, the response surface method of three factors with three levels were employed, and the yield of target compound in the reaction system were taken as the response value to analyze the significance and interaction of the various factors. The optimal synthesis conditions were substance ratio of hydroxycitronellal to 1,2-propylene glycol 1∶3. 5, reaction temperature 38 ℃, reaction time 4. 4 h, and substance ratio of hydroxycitronellal to toluene 1∶2 -1∶2. 5. Under the optimal conditions, the yield of target compound was 89. 76 %.