CAJ | 학술논문

对1990年12月~2013年4月本院收治的25例重症多形红斑（SJS）和17例中毒性表皮坏死松解症（TEN）患者的临床资料进行回顾性分析。探讨SJS和TEN的致敏因素、发生规律、临床特征和治疗措施。药物是引起SJS和TEN的最主要病因。致敏药物以抗菌药物为主（52.38%），其次是抗癫痫药（28.57%）。黏膜损害和肝功能损害是最常见的并发症。 SJS和TEN均系统应用糖皮质激素治疗，SJS组8例和TEN组4例给予激素联合人免疫球蛋白治疗。系统应用糖皮质激素尤其是联合人免疫球蛋白治疗SJS和TEN有效。
대1990년12월~2013년4월본원수치적25례중증다형홍반（SJS）화17례중독성표피배사송해증（TEN）환자적림상자료진행회고성분석。탐토SJS화TEN적치민인소、발생규률、림상특정화치료조시。약물시인기SJS화TEN적최주요병인。치민약물이항균약물위주（52.38%），기차시항전간약（28.57%）。점막손해화간공능손해시최상견적병발증。 SJS화TEN균계통응용당피질격소치료，SJS조8례화TEN조4례급여격소연합인면역구단백치료。계통응용당피질격소우기시연합인면역구단백치료SJS화TEN유효。
The clinical data of hospitalized patients of 25 cases of Stevens Johnson syndrome (SJS) and 17 cases of toxic epidermal necrolysis (TEN) were reviewed retrospectively from 1990 to 2013, to study the general patterns of the development of SJS and TEN, the clinical features and appropriate therapies. SJS and TEN had often been caused by drug reactions. The major sensitizing drugs were antibiotics (52.38%) and antiepileptics (28.57%). Hepatitis and mucosal damage were the most common organ damage in both SJS and TEN. Systemic corticosteroids were used in 25 cases of SJS and 17 cases of TEN, among which 8 cases of SJS and 4 cases of TEN were treated with immunoglobulin combined with corticosteroid. Systemic therapy with corticosteroids especially treated with combined therapy of immunoglobulin and corticosteroid have beneficial effects on SJS and TEN.