CAJ | 학술논문

目的：探讨电针曲池穴、神门穴对心肌肥厚模型大鼠血管紧张素Ⅱ及内皮素1影响。方法：SD大鼠50只随机分为假手术组、模型组、曲池组、神门组、曲池加神门组，每组10只，建立腹主动脉缩窄法心肌肥厚大鼠模型，电针组采用连续波，连续治疗14天，通过放射免疫法测定血浆和心肌组织中血管紧张素Ⅱ及内皮素1的含量。结果：曲池组、神门组、曲池加神门组的血浆和心肌组织中血管紧张素Ⅱ及内皮素1的含量治疗后与模型组相比，有显著性差异（P＜0．05或P＜0．01）。结论：电针曲池加神门可以明显抑制腹主动脉缩窄法引起的心肌肥厚，分子生物学的机制可能是通过降低血管紧张素Ⅱ及内皮素1进而发挥抗心肌肥厚的作用。
목적：탐토전침곡지혈、신문혈대심기비후모형대서혈관긴장소Ⅱ급내피소1영향。방법：SD대서50지수궤분위가수술조、모형조、곡지조、신문조、곡지가신문조，매조10지，건립복주동맥축착법심기비후대서모형，전침조채용련속파，련속치료14천，통과방사면역법측정혈장화심기조직중혈관긴장소Ⅱ급내피소1적함량。결과：곡지조、신문조、곡지가신문조적혈장화심기조직중혈관긴장소Ⅱ급내피소1적함량치료후여모형조상비，유현저성차이（P＜0．05혹P＜0．01）。결론：전침곡지가신문가이명현억제복주동맥축착법인기적심기비후，분자생물학적궤제가능시통과강저혈관긴장소Ⅱ급내피소1진이발휘항심기비후적작용。
Objective:To discuss the effect of electroacupuncture at Quchi and Shenmen on angiotensinⅡand endothelin 1 in rats with cardiac hypertrophy.Methods:Fifty SD rats were randomly divided into five groups by random as sham operation group,model group,Quchi group,Shenmen group,Quchi and Shenmen group,with ten rats in each group.The cardiac hypertrophy model of rat was prepared and rats in electroacupuncture group were received a continuous wave for successive 14 days.Through the method of radioimmunoassay, the concentra-tions of angiotensinⅡand endothelin 1 in blood plasma and heart tissue were detected.Results:After the treat-ment,the concentrations of angiotensinⅡand endothelin in blood plasma and heart tissue were significantly low-er in Quchi group, Shenmen group,Quchi and Shenmen group than those in model group( P<0.05 or P<0.01 ) .Conclusion:Electroacupuncture at Quchi and Shenmen acupoints can prevent the myocardial hypertrophy hydrochloride induced by abdominal aortic banding through decreasing the contents of angiotensinⅡand endothelin 1.