CAJ | 학술논문

目的：观察针刺对系膜增生性肾小球肾炎（ MsPGN）大鼠肾组织的显微结构与超微结构的病理改变，为针刺治疗MsPGN提供形态学依据。方法：采用综合免疫方法建立MsPGN大鼠模型，选取命门、双肾俞、关元、中脘等穴位进行针刺治疗，光学显微镜和透射电子显微镜下观察其肾脏病理学改变。结果：与模型组比较，各针刺组肾小球系膜细胞和基质增生减少；系膜区宽度明显下降（ P ＜0．05，P ＜0．01），系膜区电子致密物消失；足细胞超微结构损伤程度明显减轻。结论：针刺对MsPGN大鼠具有一定的治疗作用。
목적：관찰침자대계막증생성신소구신염（ MsPGN）대서신조직적현미결구여초미결구적병리개변，위침자치료MsPGN제공형태학의거。방법：채용종합면역방법건립MsPGN대서모형，선취명문、쌍신유、관원、중완등혈위진행침자치료，광학현미경화투사전자현미경하관찰기신장병이학개변。결과：여모형조비교，각침자조신소구계막세포화기질증생감소；계막구관도명현하강（ P ＜0．05，P ＜0．01），계막구전자치밀물소실；족세포초미결구손상정도명현감경。결론：침자대MsPGN대서구유일정적치료작용。
Objective:By observing the pathological changes of microstructure and ultrastructure of acupuncture on mesangial proliferative glomerulonephritis ( MsPGN) in rats, to investigate the morphological mechanisms of prevention and treatment of MsPGN.Methods:The mesangial proliferative glomerulonephritis ( MsPGN ) rat models were induced by comprehensive immunization.Acupuncture treatment at Mingmen point,Shuangshenyu points Guanyuan point and Zhongwan point was used for the MsPGN rats,and the pathological changes were ob-served in kidney by LM and TEM.Results:Both of the acupuncture groups were compared with the model group.The mesangial cell and matrix were obviously decreased; the mesangial region had narrowed down( P<0.05,P<0.01);mesangial immune deposits disappeared and the damage of feet epithelial cells were reduced. Conclusion:The acupuncture has some therapeutic effect on MsPGN rats.