中医正骨
中醫正骨
중의정골
THE JOURNAL OF TRADITIONAL CHINESE ORTHOPEDICS AND TRAUMATOLOGY
2014年
12期
7-9
,共3页
骨质疏松,绝经后%骨质疏松性骨折%髋骨折%益气%温经%强骨饮%骨密度%骨生成%骨吸收
骨質疏鬆,絕經後%骨質疏鬆性骨摺%髖骨摺%益氣%溫經%彊骨飲%骨密度%骨生成%骨吸收
골질소송,절경후%골질소송성골절%관골절%익기%온경%강골음%골밀도%골생성%골흡수
Osteoporosis,postmenopausal%Osteoporotic fractures%Hip fractures%Reinforcing QI%Warming meridians%Qianggu Yin%Bone mineral density%Osteogenesis%Bone resorption
目的：观察益气温经法对绝经后骨质疏松性髋部骨折患者骨形成和骨吸收指标的影响。方法：将符合要求的75例绝经后骨质疏松性单侧髋部骨折患者随机分为2组，中药组37例、对照组38例。髋部骨折手术后，对照组口服钙尔奇D片和阿法骨化醇胶囊，每天1次，服用6个月，同时指导患者进行规范的功能锻炼；中药组在对照组用药及功能锻炼的基础上口服强骨饮进行治疗，强骨饮每天2次，服用6个月。分别于治疗前和治疗6个月后测定2组患者的骨密度、Ⅰ型胶原N前端肽和Ⅰ型胶原C末端肽血清含量。结果：治疗前2组患者腰椎骨密度比较，差异无统计学意义[（0．757±0．067）g·cm－2，（0．753±0．065）g·cm－2， t＝0．297，P＝0．767]；治疗6个月后，2组患者的腰椎骨密度均增大，中药组骨密度的增加值大于对照组[（0．018±0．025） g·cm－2，（0．005±0．027）g·cm－2，t＝2．078，P＝0．041]。治疗前2组患者的Ⅰ型胶原N前端肽和Ⅰ型胶原C末端肽血清含量比较，组间差异均无统计学意义[（46．27±9．35）ng·mL－1，（43．73±9．39）ng·mL－1，t＝1．175，P＝0．244；（0．577±0．236） ng·mL－1，（0．550±0．206）ng·mL－1，t＝0．530，P＝0．598]；治疗6个月后中药组患者的Ⅰ型胶原N前端肽和Ⅰ型胶原C末端肽血清含量均小于对照组[（35．16±6．76）ng·mL－1，（46．61±9．04）ng·mL－1，t＝6．198，P＝0．000；（0．304±0．078）ng·mL－1，（0．422±0．180）ng·mL－1，t＝3．744，P＝0．000]。结论：益气温经法可通过降低Ⅰ型胶原N前端肽和Ⅰ型胶原C末端肽的血清含量，抑制骨骼的高转换状态，提高骨量，达到防治绝经后骨质疏松性髋部骨折的目的。
目的：觀察益氣溫經法對絕經後骨質疏鬆性髖部骨摺患者骨形成和骨吸收指標的影響。方法：將符閤要求的75例絕經後骨質疏鬆性單側髖部骨摺患者隨機分為2組，中藥組37例、對照組38例。髖部骨摺手術後，對照組口服鈣爾奇D片和阿法骨化醇膠囊，每天1次，服用6箇月，同時指導患者進行規範的功能鍛煉；中藥組在對照組用藥及功能鍛煉的基礎上口服彊骨飲進行治療，彊骨飲每天2次，服用6箇月。分彆于治療前和治療6箇月後測定2組患者的骨密度、Ⅰ型膠原N前耑肽和Ⅰ型膠原C末耑肽血清含量。結果：治療前2組患者腰椎骨密度比較，差異無統計學意義[（0．757±0．067）g·cm－2，（0．753±0．065）g·cm－2， t＝0．297，P＝0．767]；治療6箇月後，2組患者的腰椎骨密度均增大，中藥組骨密度的增加值大于對照組[（0．018±0．025） g·cm－2，（0．005±0．027）g·cm－2，t＝2．078，P＝0．041]。治療前2組患者的Ⅰ型膠原N前耑肽和Ⅰ型膠原C末耑肽血清含量比較，組間差異均無統計學意義[（46．27±9．35）ng·mL－1，（43．73±9．39）ng·mL－1，t＝1．175，P＝0．244；（0．577±0．236） ng·mL－1，（0．550±0．206）ng·mL－1，t＝0．530，P＝0．598]；治療6箇月後中藥組患者的Ⅰ型膠原N前耑肽和Ⅰ型膠原C末耑肽血清含量均小于對照組[（35．16±6．76）ng·mL－1，（46．61±9．04）ng·mL－1，t＝6．198，P＝0．000；（0．304±0．078）ng·mL－1，（0．422±0．180）ng·mL－1，t＝3．744，P＝0．000]。結論：益氣溫經法可通過降低Ⅰ型膠原N前耑肽和Ⅰ型膠原C末耑肽的血清含量，抑製骨骼的高轉換狀態，提高骨量，達到防治絕經後骨質疏鬆性髖部骨摺的目的。
목적：관찰익기온경법대절경후골질소송성관부골절환자골형성화골흡수지표적영향。방법：장부합요구적75례절경후골질소송성단측관부골절환자수궤분위2조，중약조37례、대조조38례。관부골절수술후，대조조구복개이기D편화아법골화순효낭，매천1차，복용6개월，동시지도환자진행규범적공능단련；중약조재대조조용약급공능단련적기출상구복강골음진행치료，강골음매천2차，복용6개월。분별우치료전화치료6개월후측정2조환자적골밀도、Ⅰ형효원N전단태화Ⅰ형효원C말단태혈청함량。결과：치료전2조환자요추골밀도비교，차이무통계학의의[（0．757±0．067）g·cm－2，（0．753±0．065）g·cm－2， t＝0．297，P＝0．767]；치료6개월후，2조환자적요추골밀도균증대，중약조골밀도적증가치대우대조조[（0．018±0．025） g·cm－2，（0．005±0．027）g·cm－2，t＝2．078，P＝0．041]。치료전2조환자적Ⅰ형효원N전단태화Ⅰ형효원C말단태혈청함량비교，조간차이균무통계학의의[（46．27±9．35）ng·mL－1，（43．73±9．39）ng·mL－1，t＝1．175，P＝0．244；（0．577±0．236） ng·mL－1，（0．550±0．206）ng·mL－1，t＝0．530，P＝0．598]；치료6개월후중약조환자적Ⅰ형효원N전단태화Ⅰ형효원C말단태혈청함량균소우대조조[（35．16±6．76）ng·mL－1，（46．61±9．04）ng·mL－1，t＝6．198，P＝0．000；（0．304±0．078）ng·mL－1，（0．422±0．180）ng·mL－1，t＝3．744，P＝0．000]。결론：익기온경법가통과강저Ⅰ형효원N전단태화Ⅰ형효원C말단태적혈청함량，억제골격적고전환상태，제고골량，체도방치절경후골질소송성관부골절적목적。
Objective:To observe the effect of the therapeutic methods(TCM)of Reinforcing QI Warming Meridians on bone turnoverindicators in patients with postmenopausal osteoporotic hip fracture.Methods:Seventy-five patients with unilateral postmenopausal osteoporotichip fracture enrolled in the study were randomly divided into traditional chinese medicine(TCM)group(37 cases)and control group(38 cases).The patients in control group were treated with oral application of Caltrate D tablets and Alfacalcidol capsules,once a day forconsecutive 6 months.Meanwhile,normative functional exercises were performed with guidance from nurses.The patients in TCMgroup weretreated with not only the same treatment but also oral application of Qianggu Yin(强骨饮)twice a day for consecutive 6 months.Bone mineraldensity(BMD)and serum concentrations of procollagenⅠN-terminal propeptide(PⅠNP)and collagen typeⅠC-terminal cross-linkedtelopeptide(CTX)were measured and compared between the 2 groups before treatment and after 6-month treatment respectively.Results:There was no statistical difference in lumbar vertebrae BMD between the 2 groups before the treatment(0.757 +/-0.067 vs 0.753 +/-0.065 g/cm(2),t =0.297,P =0.767),while the lumbar vertebrae BMD increased in both of the 2 groups after 6-month treatment and theincrease value was greater in TCMgroup(0.018 +/-0.025 vs 0.005 +/-0.027 g/cm(2),t =2.078,P =0.041).There was no statisticaldifference in the serum concentrations of PⅠNP and CTX between the 2 groups before the treatment(46.27 +/-9.35 vs 43.73 +/-9.39 ng/ml,t =1.175,P =0.244;0.577 +/-0.236 vs 0.550 +/-0.206 ng/ml,t =0.530,P =0.598),while the serum concentrations ofPⅠNP and CTX were lower in the TCM group compared with the control group after 6-month treatment(35.16 +/-6.76 vs 46.61 +/-9.04 ng/ml,t =6.198,P =0.000;0.304 +/-0.078 vs 0.422 +/-0.180 ng/ml,t =3.744,P =0.000).Conclusion:The therapeuticmethods(TCM)of Reinforcing QI Warming Meridians can inhibit the high bone transition and increase bone mass by means of reducing theserum concentrations of PⅠNP and CTX,so it can prevent the postmenopausal osteoporotic hip fractures.
