CAJ | 학술논문

MicroRNAs（ miRNAs）是一类长约20个核苷酸的内源性非编码小分子RNA，其表达紊乱或功能异常可导致其靶基因调节异常，从而参与肿瘤发生、发展。胃癌为全球高发的恶性肿瘤，目前已发现多种miRNAs及其作用靶点与胃癌细胞的增殖、迁移、侵袭、凋亡以及化疗敏感性密切相关。本文就胃癌相关miRNAs及其作用靶点以及靶向miRNAs在胃癌治疗中应用的研究进展作一综述。
MicroRNAs（ miRNAs）시일류장약20개핵감산적내원성비편마소분자RNA，기표체문란혹공능이상가도치기파기인조절이상，종이삼여종류발생、발전。위암위전구고발적악성종류，목전이발현다충miRNAs급기작용파점여위암세포적증식、천이、침습、조망이급화료민감성밀절상관。본문취위암상관miRNAs급기작용파점이급파향miRNAs재위암치료중응용적연구진전작일종술。
MicroRNAs( miRNAs)are a family of endogenous noncoding small RNA molecules that are approximately 20 nucleotides in length. Aberrant expression or dysfunction of miRNAs and subsequent dysregulation of their target genes might be involved in the occurrence and development of various cancers. Gastric cancer is a leading malignant disease worldwide. Recent studies have shown that some miRNAs are closely associated with the proliferation,migration,invasion, apoptosis and chemosensitivity of gastric cancer cells by regulating their target genes. Advances in study on gastric cancer-related miRNAs,their target genes,and the use of miRNAs-targeted therapy in gastric cancer were reviewed in this article.