CAJ | 학술논문

目的：探讨34βE12在乳腺浸润性小叶癌(ILC)中的表达对临床病理及预后判断的意义。方法采用免疫组织化学 S-P 法观察34βE12在72例 ILC 和354例乳腺浸润性导管癌(IDC)中表达的差异，并观察在72例 ILC 中34βE12的表达与发病年龄、肿瘤大小、核多形性程度、核分裂计数、淋巴结转移、pTNM 分期、ER/ PR/ HER-2等临床病理特征以及临床随访的关系。结果①34βE12在 ILC 和 IDC 中阳性率分别为44．4%和36．2%，表达差异无统计学意义( P =0．186)。②34βE12在肿瘤大小组、核多形性组、核分裂计数组、ER、PR、HER-2中表达的差异均有统计学意义(P =0．020、0．007、0．030、0．001、0．004、0．041)；34βE12在年龄组、淋巴结转移组、pTNM 分期组中表达差异无统计学意义(P =0．709、0．065、0．100)。③34βE12在术后复发率、生存率组中表达的差异有统计学意义(P <0．05)。结论34βE12对 ILC 与IDC 的鉴别诊断意义有限；34βE12阳性的 ILC 倾向于肿瘤体积大、细胞核异型性大、核分裂像多、ER/ PR/ HER-2阴性，临床随访容易术后复发、死亡率较高；ILC 可能存在基底细胞样亚型。
목적：탐토34βE12재유선침윤성소협암(ILC)중적표체대림상병리급예후판단적의의。방법채용면역조직화학 S-P 법관찰34βE12재72례 ILC 화354례유선침윤성도관암(IDC)중표체적차이，병관찰재72례 ILC 중34βE12적표체여발병년령、종류대소、핵다형성정도、핵분렬계수、림파결전이、pTNM 분기、ER/ PR/ HER-2등림상병리특정이급림상수방적관계。결과①34βE12재 ILC 화 IDC 중양성솔분별위44．4%화36．2%，표체차이무통계학의의( P =0．186)。②34βE12재종류대소조、핵다형성조、핵분렬계수조、ER、PR、HER-2중표체적차이균유통계학의의(P =0．020、0．007、0．030、0．001、0．004、0．041)；34βE12재년령조、림파결전이조、pTNM 분기조중표체차이무통계학의의(P =0．709、0．065、0．100)。③34βE12재술후복발솔、생존솔조중표체적차이유통계학의의(P <0．05)。결론34βE12대 ILC 여IDC 적감별진단의의유한；34βE12양성적 ILC 경향우종류체적대、세포핵이형성대、핵분렬상다、ER/ PR/ HER-2음성，림상수방용역술후복발、사망솔교고；ILC 가능존재기저세포양아형。
Objective To investigate the significance of expressions of 34βE12 with clinicopathology and prognosis in in-vasive lobular carcinoma (ILC) of the breast. Methods The S-P immunohistochemical method was performed to determine the different expressions of 34βE12 between in 72 cases of ILC and in 354 cases of invasive ductal carcinoma(IDC) and determine the relationship between expressions of 34βE12 and clinicopathological characteristics in 72 cases of ILC. Results ①The positive rates of 34βE12 were 44. 4% and 36. 2% in ILC and IDC. There was no statistically significant difference between them (P =0. 186). ②The differences of expressions of 34βE12 were statistically significant in tumor size group,nuclear grade group,caryoki-nesis index group,ER/ PR/ HER-2 groups ( P = 0. 020,0. 007,0. 030,0. 001,0. 004,0. 041). The differences of expression of 34βE12 were not statistically significant in age group,lymph node status group and pTNM stage group(P = 0. 709,0. 065,0. 100).③The differences of expressions of 34βE12 were statistically significant both in the recurrence rate group and in the mortality rate group(P < 0. 05). Conclusion There is not differential significance about 34βE12 expressions between in ILC and in IDC. The diagnosis significance is limited. The positive expression of 34βE12 is prone tohuge tumor size,high nuclear grade,high caryokine-sis index,ER/ PR/ HER-2 negative expressions,high mortality andhigh recurrence rate in ILC,thus suggests basal-like type proba-bly present in ILC.