CAJ | 학술논문

目的：探讨妊娠早期检测孕酮(P)、雌二醇(E 2)、血绒毛膜促性腺激素(HCG)的动态变化对妊娠结局的预测价值。方法选择自然周期监测排卵后怀孕者228例,根据妊娠结局分为3组：正常妊娠组、流产组、宫外孕组。以排卵日为0d,首次检测排卵后15~17d 的血清雌二醇、孕酮、绒毛膜促性腺激素,间隔2~3d 后第2次检测,再间隔7d 第3次检测,间隔10d 以上第4次检测。比较不同间隔时间3种激素的差异。进一步比较雌二醇差值的增减比例。结果正常宫内孕组雌二醇、绒毛膜促性腺激素呈增长趋势,孕酮变化较小。流产组雌二醇、孕酮下降,绒毛膜促性腺激素有增有降,且增幅明显小于正常宫内孕组。宫外孕组雌二醇波动小,孕酮、绒毛膜促性腺激素呈下降趋势。雌二醇增加者在正常宫内孕组为91．3%,流产组为6．12%,宫外孕组为73．17%,差异有统计学意义(P <0．05)。结论在妊娠早期尚不能靠B 超确定妊娠结局前,检测血清雌二醇、孕酮、绒毛膜促性腺激素的动态变化对妊娠结局有预测价值。
목적：탐토임신조기검측잉동(P)、자이순(E 2)、혈융모막촉성선격소(HCG)적동태변화대임신결국적예측개치。방법선택자연주기감측배란후부잉자228례,근거임신결국분위3조：정상임신조、유산조、궁외잉조。이배란일위0d,수차검측배란후15~17d 적혈청자이순、잉동、융모막촉성선격소,간격2~3d 후제2차검측,재간격7d 제3차검측,간격10d 이상제4차검측。비교불동간격시간3충격소적차이。진일보비교자이순차치적증감비례。결과정상궁내잉조자이순、융모막촉성선격소정증장추세,잉동변화교소。유산조자이순、잉동하강,융모막촉성선격소유증유강,차증폭명현소우정상궁내잉조。궁외잉조자이순파동소,잉동、융모막촉성선격소정하강추세。자이순증가자재정상궁내잉조위91．3%,유산조위6．12%,궁외잉조위73．17%,차이유통계학의의(P <0．05)。결론재임신조기상불능고B 초학정임신결국전,검측혈청자이순、잉동、융모막촉성선격소적동태변화대임신결국유예측개치。
Objective To investigate the dynamic changes of serum estradiol(E 2 ),progesterone(P)andhuman chorionic gonadotropin(HCG)on the predictive value of early pregnancy. Methods Choose 228 pregnant women after ovulation monitoring in natural cycle. According pregnancy outcomes,they were divided into 3 groups: normal pregnancy group,abortion,ectopic preg-nancy group. Set the ovulation day is 0 day,test the serum level of E 2 ,P and HCG on 15 ~ 17 day firstly,the second test after 2 ~3 days,third test after 7 days,and last test after 10 days. Compare the differences of hormonal on different intervals in three groups. Results E 2 and HCG had growing trends in normal pregnancy group,however P had small changes. E 2 and P decreased in abor-tion group,P was fluctuated,and the increase was significantly less than in the normal group. P and HCG were declined in the ec-topic pregnancy group, and E 2 had small changes. E 2 increases in normal pregnancy group were 91. 3% , abortion group was 6. 12% ,and ectopic pregnancy group was 73. 17% (P < 0. 05). Conclusion In early pregnancy,dynamic changes of serum E 2 ,P and HCG level shave predictive value of pregnancy outcome before it can be determined by ultrasound.