CAJ | 학술논문

目的：探讨过敏原检测在药物性肝损害(DILI)患者中的临床意义。方法选择200例临床诊断为 DILI 的住院患者进行血清过敏原检测，同时检测200例正常人血清过敏原作为对照。结果200例 DILI 患者血清过敏原检测阳性率为76．5%(153/200)，其吸入性过敏原与食入性过敏原阳性率比较差异无统计学意义(P >0．05)。阳性率较高的为尘螨/粉螨、普通豚草/蒿属植物、蟹/虾/龙虾、牛肉/羊肉。而正常人血清过敏原阳性率为20%(40/200)，差异有统计学意义(P <0．01)。结论 DILI 患者具有较高的血清过敏原检测阳性率，过敏原检测可以了解 DILI 患者的过敏体质状况，指导患者避免或减少过敏原接触，对患者在临床用药方面有一定指导作用。
목적：탐토과민원검측재약물성간손해(DILI)환자중적림상의의。방법선택200례림상진단위 DILI 적주원환자진행혈청과민원검측，동시검측200례정상인혈청과민원작위대조。결과200례 DILI 환자혈청과민원검측양성솔위76．5%(153/200)，기흡입성과민원여식입성과민원양성솔비교차이무통계학의의(P >0．05)。양성솔교고적위진만/분만、보통돈초/호속식물、해/하/룡하、우육/양육。이정상인혈청과민원양성솔위20%(40/200)，차이유통계학의의(P <0．01)。결론 DILI 환자구유교고적혈청과민원검측양성솔，과민원검측가이료해 DILI 환자적과민체질상황，지도환자피면혹감소과민원접촉，대환자재림상용약방면유일정지도작용。
Objective To discuss the clinical significance of allergy testing in patients with drug-induced liver injury. Methods 200 cases with DILI were given test serum allergens,and 200 cases were compared with normals. Results The positive rate of serum allergens in 200 DILI was 76. 5% (153 / 200);There were no statistically significant differences between inhaled al-lergens and food allergens(P > 0. 05). Thehigher positive allergens were dust mites/ powder mite,ordinary ragweed/ from plants, crab/ shrimp/ lobster and beef/ lamb. And serum specific allergen positive rate of normals was only 20% (40 / 200),there was statis-tically significant difference between DILI and normals(P < 0. 01). Conclusion DILI patientshadhigher allergens tested positive rate,it canhelp know about allergen situation through serum allergens detection,and there are some certain significance for patients to avoid or reduce exposure to the allergen,andhave a guiding role in terms of clinical medicine for patients.