CAJ | 학술논문

目的：探讨血浆五聚素3(Pentraxin-3, PTX-3)在评估急性冠状动脉综合征(acute coronary syndrome, ACS)病情严重程度中的作用。方法选择ACS患者90例,根据美国心脏病学学院/美国心脏学会( ACC/AHA)指南分为不稳定型心绞痛组( UAP 组)26例, ST 段抬高型心肌梗死组31例( STEMI 组),非 ST 段抬高型心肌梗死组(NSTEMI组)33例,另选同期健康体检者30例作为对照组。采用酶联免疫吸附试验(ELISA)检测血清PTX-3及全自动生化分析仪检测血清超敏C反应蛋白( hs-CRP)并进行组间比较。结果血清PTX-3和hs-CRP水平UAP组、STE-MI组和NSTEMI组显著高于对照组( P<0．05), STEMI组和NSTEMI组显著高于UAP组,差异均有统计学意义( P均<0.05),但 STEMI组和 NSTEMI组比较差异无统计学意义(P>0．05)。相关分析显示血清 PTX-3与总胆固醇(TC)、甘油三酯(TG)及低密度脂蛋白胆固醇(LDL-C)、hs-CRP呈明显正相关(r=0.484,r=0.572,r=0.587,r=0．866；P均<0.01),与高密度脂蛋白胆固醇(HDL-C)呈明显负相关(r=-0.497,P<0．01)。结论血清PTX-3参与了ACS的发生、发展,可用于ACS患者的病情评估。
목적：탐토혈장오취소3(Pentraxin-3, PTX-3)재평고급성관상동맥종합정(acute coronary syndrome, ACS)병정엄중정도중적작용。방법선택ACS환자90례,근거미국심장병학학원/미국심장학회( ACC/AHA)지남분위불은정형심교통조( UAP 조)26례, ST 단태고형심기경사조31례( STEMI 조),비 ST 단태고형심기경사조(NSTEMI조)33례,령선동기건강체검자30례작위대조조。채용매련면역흡부시험(ELISA)검측혈청PTX-3급전자동생화분석의검측혈청초민C반응단백( hs-CRP)병진행조간비교。결과혈청PTX-3화hs-CRP수평UAP조、STE-MI조화NSTEMI조현저고우대조조( P<0．05), STEMI조화NSTEMI조현저고우UAP조,차이균유통계학의의( P균<0.05),단 STEMI조화 NSTEMI조비교차이무통계학의의(P>0．05)。상관분석현시혈청 PTX-3여총담고순(TC)、감유삼지(TG)급저밀도지단백담고순(LDL-C)、hs-CRP정명현정상관(r=0.484,r=0.572,r=0.587,r=0．866；P균<0.01),여고밀도지단백담고순(HDL-C)정명현부상관(r=-0.497,P<0．01)。결론혈청PTX-3삼여료ACS적발생、발전,가용우ACS환자적병정평고。
Objective To explore the roles of PTX-3 in the assessment of the severity of acute coronary syndromes. Methods 90 patients with acute coronary syndrome were divided into unstable angina pectoris (UAP) group (n=26), ST segment elevation MI (STEMI) group (n=31), and non-ST segment elevation MI (NSTEMI) group (n=33) according to guidelines of ACC/AHA. 30 healthy volunteers were enrolled as control group. Serum PTX-3 level were measured with en-zyme-linked absorbed assay. The level of hs-CRP was determined by using an automated measurement method. Results The levels of PTX-3 and hs-CRP in UAP, STEMI and NSTEMI groups were significantly higher than those in the control group (P<0. 05). The levels of PTX-3 and hs-CRP in STEMI and NSTEMI groups were significantly higher than those in UAP group, all with significant differences ( P<0. 05 ) . There was no significant difference between STEMI group and NSTEMI group. Pearson collection analysis, serum PTX-3 level were positively correlated with the levels of total cholesterol ( TC) , tri-glyceride (TG), low density lipoprotein cholesterol (LDL-C) and hs-CRP (r=0. 484, r=0. 572, r=0. 587, r=0. 866;P<0. 01), was negatively correlated with the level of high density lipoprotein cholesterol (HDL-C) (r = -0. 497, P <0. 01). Conclusion The level of serum PTX-3 may play an important role in the pathogenesis of ACS and may be useful in assessment of the severity of acute coronary syndrome.