甘肃医药
甘肅醫藥
감숙의약
Gansu Medical Journal
2014年
12期
899-902
,共4页
2型糖尿病%血管病变%金属蛋白酶9%同型半胱氨酸
2型糖尿病%血管病變%金屬蛋白酶9%同型半胱氨痠
2형당뇨병%혈관병변%금속단백매9%동형반광안산
type 2 diabete%vascular pathological changes%matrix metalloproteinase 9%homocysteine
目的：探讨2型糖尿病（T2DM）血管病变患者血清金属蛋白酶9（MMP9）水平、同型半胱氨酸（Hcy）水平、各自影响因素及二者间的关系。方法：测定66名2型糖尿病患者和20名健康人MMP9、Hcy及各相关临床生化指标，并对各因素进行相关分析。结果：2型糖尿病大血管病变组血清中MMP9和Hcy浓度显著高于单纯2型糖尿病组和正常组，但低于糖尿病肾病组。Hcy水平与年龄均正相关；MMP9与低密度脂蛋白（LDL）、胆固醇（CHO）、甘油三脂（TG）、血压和Hcy呈正相关，与高密度脂蛋白（HDL）呈负相关。结论：血清中的MMP9和Hcy浓度的检测对2型糖尿病血管病变的发生、发展有重要临床意义。
目的：探討2型糖尿病（T2DM）血管病變患者血清金屬蛋白酶9（MMP9）水平、同型半胱氨痠（Hcy）水平、各自影響因素及二者間的關繫。方法：測定66名2型糖尿病患者和20名健康人MMP9、Hcy及各相關臨床生化指標，併對各因素進行相關分析。結果：2型糖尿病大血管病變組血清中MMP9和Hcy濃度顯著高于單純2型糖尿病組和正常組，但低于糖尿病腎病組。Hcy水平與年齡均正相關；MMP9與低密度脂蛋白（LDL）、膽固醇（CHO）、甘油三脂（TG）、血壓和Hcy呈正相關，與高密度脂蛋白（HDL）呈負相關。結論：血清中的MMP9和Hcy濃度的檢測對2型糖尿病血管病變的髮生、髮展有重要臨床意義。
목적：탐토2형당뇨병（T2DM）혈관병변환자혈청금속단백매9（MMP9）수평、동형반광안산（Hcy）수평、각자영향인소급이자간적관계。방법：측정66명2형당뇨병환자화20명건강인MMP9、Hcy급각상관림상생화지표，병대각인소진행상관분석。결과：2형당뇨병대혈관병변조혈청중MMP9화Hcy농도현저고우단순2형당뇨병조화정상조，단저우당뇨병신병조。Hcy수평여년령균정상관；MMP9여저밀도지단백（LDL）、담고순（CHO）、감유삼지（TG）、혈압화Hcy정정상관，여고밀도지단백（HDL）정부상관。결론：혈청중적MMP9화Hcy농도적검측대2형당뇨병혈관병변적발생、발전유중요림상의의。
Objective:To explore the relationship between Matrix metalloproteinase 9 and Homocysteine in vascular pathological changes of type 2 diabete patients. Methods: The serum MMP9 and Hcy were determined in 66 patients with type 2 diabetes(including 20 cases of type 2 diabetes without complication,22 cases of type 2 diabetes macroangiopathy and 24 cases of diabetic nephropathy) and 20 healthy controls in which clinical and biochemical data were analysed. Results: MMP9 and Hcy concentration in type 2 diabetes with macroangiopathy group were high than that in serum of type 2 diabetes group and normal group, but were lower than that in diabetic nephropathy. Serum MMP9 was correlated positively with LDL、 CHO、TG、blood pressure、Hcy and correlated negatively with HDL . Conclusion: There is important clinical significance of detection of MMP9 in serum and Hcy concentration on vascular complications in occurrence and development of type 2 diabetes.
