CAJ | 학술논문

在运动科学领域中,研究者通过测定分别产生IFN-y(或IL-2)与IL-4的外周血、脾脏细胞计数(或百分比),脾脏与外周血细胞在培养与刺激条件下分泌Th1、Th2类细胞因子的水平,以及血液中相关细胞因子含量的方法,从细胞数量与功能上来评价运动中机体的免疫平衡状态。分析认为：(1)Th1、Th2细胞在运动中的变化趋势分别与Tc1、Tc2细胞保持一致,Th1/Th2平衡能间接反映T1/T2平衡的变化。(2)相比细胞数量,细胞因子可能更能有效评价运动中的Th1/Th2平衡。(3)通过淋巴细胞分泌的相关细胞因子水平来评价运动中Th1/Th2平衡时,刺激物等实验条件可影响实验结果。(4)循环血中IFN-y、IL-4的含量可用于间接评定运动中的Th1/Th2平衡。通过对运动中Th1/Th2平衡评价方法的分析与评述,以期为未来相关研究的设计提供依据,为其成果内容的表述提供参考。
재운동과학영역중,연구자통과측정분별산생IFN-y(혹IL-2)여IL-4적외주혈、비장세포계수(혹백분비),비장여외주혈세포재배양여자격조건하분비Th1、Th2류세포인자적수평,이급혈액중상관세포인자함량적방법,종세포수량여공능상래평개운동중궤체적면역평형상태。분석인위：(1)Th1、Th2세포재운동중적변화추세분별여Tc1、Tc2세포보지일치,Th1/Th2평형능간접반영T1/T2평형적변화。(2)상비세포수량,세포인자가능경능유효평개운동중적Th1/Th2평형。(3)통과림파세포분비적상관세포인자수평래평개운동중Th1/Th2평형시,자격물등실험조건가영향실험결과。(4)순배혈중IFN-y、IL-4적함량가용우간접평정운동중적Th1/Th2평형。통과대운동중Th1/Th2평형평개방법적분석여평술,이기위미래상관연구적설계제공의거,위기성과내용적표술제공삼고。
In the field of sports science, the number/percentage of IFN-y (or IL-2) and IL-4 cells in periph-eral blood or spleen, the levels of Th1, Th2-associated cytokines produced by the cells, and the concentrations of the cytokines in circulation are measured by researchers to evaluate the Th1/Th2 balance following exercise from the per-spective of Th1and Th2 cell numbers and function. The analysis believes that (1) The change of Th1 and Th2 cells in response to exercise is the same as that of Tc1 and Tc2 cells respectively, while Th1/Th2 balance can be used as the in-dicator of T1/T2 balance indirectly. (2) The concentration of cytokines may be the more meaningful indicators of Th1/Th2 balance in response to exercise than that of cell numbers. (3) The concentration of cytokines in the circulation may be the more meaningful indicators of Th1/Th2 balance in response to exercise than that of cytokines produced by lym-phocytes. The review is to provide the basis for study protocols and reference for discussions in the future researches through the reflection on the evaluation of Th1/Th2 balance in response to exercise.