CAJ | 학술논문

目的：以标准剂量复方聚乙二醇（ PEG）及硫酸镁方案为对照，评价新方案在结肠镜检查前肠道准备中的有效性、耐受性和安全性。方法连续收集拟行结肠镜检查者330例，随机分为三组。A组服用标准剂量PEG（68.56 g/包×2包），B组一次性服用硫酸镁（33﹪160 ml），C组连续服用小剂量PEG（1包）和硫酸镁（33﹪60 ml）行肠道准备。内镜医师用单盲法记录肠道清洁程度分级，记录结肠镜检查时间。问卷调查患者对药物的耐受性，记录服药后不良反应。监测用药前后心率、血压和实验室指标。结果所有患者均完成肠道准备和全结肠镜检查。A、C两组肠道清洁度显著高于B组（ P ﹤0.05），结肠镜检查时间显著短于B组（ P ﹤0.05）。A、C两组药物口感好评率、安全性高于B组（ P ﹤0.05），C组愿意再服用率显著高于A、B两组（ P ﹤0.05）。三组间完全服用率无显著差异（ P ﹥0.05）。结论
목적：이표준제량복방취을이순（ PEG）급류산미방안위대조，평개신방안재결장경검사전장도준비중적유효성、내수성화안전성。방법련속수집의행결장경검사자330례，수궤분위삼조。A조복용표준제량PEG（68.56 g/포×2포），B조일차성복용류산미（33﹪160 ml），C조련속복용소제량PEG（1포）화류산미（33﹪60 ml）행장도준비。내경의사용단맹법기록장도청길정도분급，기록결장경검사시간。문권조사환자대약물적내수성，기록복약후불량반응。감측용약전후심솔、혈압화실험실지표。결과소유환자균완성장도준비화전결장경검사。A、C량조장도청길도현저고우B조（ P ﹤0.05），결장경검사시간현저단우B조（ P ﹤0.05）。A、C량조약물구감호평솔、안전성고우B조（ P ﹤0.05），C조원의재복용솔현저고우A、B량조（ P ﹤0.05）。삼조간완전복용솔무현저차이（ P ﹥0.05）。결론
Objective To evaluate of new programs in the bowel preparation before colonoscopy effectiveness,tolerance and safety,using standard dose combination of polyethylene glycol( PEG)and magnesium sulfate solutions for control. Methods 330 cases continuously undergo_ing colonoscopy were randomly divided into three groups. Patients of group A took standard dose PEG(68. 56 g/pack × 2 pack),Group B dispos_able taking magnesium sulfate(33﹪ 160 ml),Group C continuous small-dose PEG(1 pack)and magnesium sulfate(33﹪ 60 ml)line bowel preparation. Endoscopists recorded intestinal cleanliness classification,recording colonoscopy time single -blind method. A questionnaire was used to assess patients′tolerance,and the adverse effects after taking the solution were recorded. Heart rate,blood pressure and various laboratory parameters were monitored before and after preparation. Results All patients completed the bowel preparation and colonoscopy. Group A and Group C were significantly higher than the intestinal cleanliness of Group B( P ﹤0. 05). The colonoscopy time was significantly shorter in group B( P ﹤0. 05). Drug taste favorable rate and safety were higher in Group A and Group C than in Group B( P ﹤0. 05). The willingness to retake in Group C was superior to those in Group A and Group B( P ﹤0. 05). No significant difference was found in score of rate of taking the solution complete among the three groups. Conclusion Compared with the standard dose of PEG and magnesium sulfate solution for taking small-dose PEG,small-dose magnesium sulfate for bowel preparation before colonoscopy is more effective,better tolerated.