CAJ | 학술논문

目的：通过检测卵巢癌患者常规凝血指标及血浆中 D-二聚体水平，探讨血浆 D-二聚体及凝血指标在卵巢癌患者中的临床应用价值。方法测定84例卵巢癌患者和25例卵巢良性肿瘤患者，分析凝血功能水平、血浆 D-二聚体水平，评估手术前血浆 D-二聚体水平在监测卵巢癌病程中的应用价值。结果卵巢癌组 D-二聚体及纤维蛋白原（FBG）水平明显高于良性肿瘤对照组（P ＜0.01）；并且卵巢癌Ⅲ～Ⅳ期患者 D-二聚体及 FBG 水平均高于卵巢癌Ⅰ～Ⅱ期患者，差异有统计学意义（P ＜0.05），提示卵巢癌患者凝血及纤溶功能障碍随病情发展呈现加重趋势。结论 D-二聚体在卵巢肿瘤时可以反映纤溶功能的过度激活，提示晚期卵巢癌患者的生存期和预后效果。D-二聚体水平在卵巢癌发生血栓的早期预防、早期诊断、早期治疗及提高预后有重要意义。
목적：통과검측란소암환자상규응혈지표급혈장중 D-이취체수평，탐토혈장 D-이취체급응혈지표재란소암환자중적림상응용개치。방법측정84례란소암환자화25례란소량성종류환자，분석응혈공능수평、혈장 D-이취체수평，평고수술전혈장 D-이취체수평재감측란소암병정중적응용개치。결과란소암조 D-이취체급섬유단백원（FBG）수평명현고우량성종류대조조（P ＜0.01）；병차란소암Ⅲ～Ⅳ기환자 D-이취체급 FBG 수평균고우란소암Ⅰ～Ⅱ기환자，차이유통계학의의（P ＜0.05），제시란소암환자응혈급섬용공능장애수병정발전정현가중추세。결론 D-이취체재란소종류시가이반영섬용공능적과도격활，제시만기란소암환자적생존기화예후효과。D-이취체수평재란소암발생혈전적조기예방、조기진단、조기치료급제고예후유중요의의。
Objective To investigate the application value of plasma D-dimer and coagulation indicators in the patients with o-varian cancer by detecting the routine coagulation indicators and plasma D-dimer level.Methods The plasma D-dimer and coagula-tion indicators levels were measured in 84 patients with ovarian cancer and 25 patients with benign ovarian tumor.The application value of preoperative plasma D-dimer level in monitoring the disease course of ovarian cancer was evaluated.Results The plasma levels of D-dimer and FBG in the ovarian cancer group were significantly higher than those in the ovarian benign tumor control group(P <0.01);moreover the plasma levels of D-dimer and FBG in the patients with the stage Ⅲ~Ⅳ ovarian cancer were signifi-cantly higher than those in the patients with the stageⅠ~Ⅱ ovarian cancer,the differences had statistical significance(P <0.05), which prompting that the coagulation and fibrinolysis dysfunction in the patients with ovarian cancer exhibited the aggravating trend with the disease condition progression.Conclusion D-dimer may reflect the excessive activation of fibrinolysis function in ovarian tumor,which prompting the survival period and prognosis in the patients with advanced ovarian cancer.The plasma D-dimer level has the important significance to early prevention,early diagnosis,early treatment and improve the prognosis in the thrombosis oc-currence in ovarian cancer.