CAJ | 학술논문

目的：探讨生活方式联合药物干预对糖调节受损合并代谢综合征患者代谢紊乱的疗效。方法选取2009年6月至2011年6月重庆市第五人民医院确诊的糖调节受损合并代谢综合征患者65例，给予生活方式联合药物的综合干预治疗，评估干预前后相关生理、生化指标的变化。结果综合干预治疗后，患者血压、空腹血糖、餐后2 h血糖、三酰甘油、总胆固醇、空腹胰岛素水平和胰岛素抵抗指数均显著降低，高密度脂蛋白水平显著增高（P＜0．05），与干预前各指标水平比较差异均有统计意义（P＜0．05）；干预前后患者体质量指数、低密度脂蛋白降低不明显，差异无统计学意义（P＞0．05）。结论综合干预能更好地降低糖调节受损合并代谢综合征患者的心血管危险因素，减少糖尿病的发生。
목적：탐토생활방식연합약물간예대당조절수손합병대사종합정환자대사문란적료효。방법선취2009년6월지2011년6월중경시제오인민의원학진적당조절수손합병대사종합정환자65례，급여생활방식연합약물적종합간예치료，평고간예전후상관생리、생화지표적변화。결과종합간예치료후，환자혈압、공복혈당、찬후2 h혈당、삼선감유、총담고순、공복이도소수평화이도소저항지수균현저강저，고밀도지단백수평현저증고（P＜0．05），여간예전각지표수평비교차이균유통계의의（P＜0．05）；간예전후환자체질량지수、저밀도지단백강저불명현，차이무통계학의의（P＞0．05）。결론종합간예능경호지강저당조절수손합병대사종합정환자적심혈관위험인소，감소당뇨병적발생。
Objective To analyze the therapeutic effect of comprehensive intervention on impaired glucose reg‐ulation combined with metabolic syndrome. Methods A total of 65 cases with impaired glucose regulation combined with metabolic syndrome, treated in this hospital during Jun. 2009 and Jun. 2011, were enrolled and treated with the comprehensive intervention. The changes of physiological and biochemical indexes were evaluated before and after in‐tervention. Results The levels of blood pressure, fast plasma glucose, 2 h plasma glucose, triacylglycerol, total cho‐lesterol, fast plasma insulin and HOMA insulin resistance index were decreased obviously after intervention (P<0. 05), the levels of high density lipoprotein‐cholesterol increased significantly(P<0. 05), while the levels of body mass index and low density lipoprotein‐cholesterol were not statistically different before and after intervention (P>0. 05). Conclusion Comprehensive intervention could significantly decrease some cardiovascular risk factors in patients with impaired glucose regulation combined with metabolic syndrome and could reduce the risks of diabetes mellitus.