海南医学
海南醫學
해남의학
HAINAN MEDICAL JOURNAL
2014年
24期
3717-3719
,共3页
黄昕%吴云涛%冉龙艳%成元华
黃昕%吳雲濤%冉龍豔%成元華
황흔%오운도%염룡염%성원화
胃肠道间质瘤%P27KIP1%P21WAF1%Bax%免疫组织化学
胃腸道間質瘤%P27KIP1%P21WAF1%Bax%免疫組織化學
위장도간질류%P27KIP1%P21WAF1%Bax%면역조직화학
Gastrointestinal stromal tumors%P27KIP1%P21WAF1%Bax%Immunohistochemistry
目的：探讨P27KIP1、P21WAF1和Bax在胃肠道间质瘤中的表达及其与临床生物学行为的相关性。方法采用免疫组化法检测P27KIP1、P21WAF1和Bax在胃肠道间质瘤中的阳性表达情况，并在良性组、潜在恶性组、恶性病例组之间进行比较。结果55例胃肠道间质瘤中，P27KIP1、P21WAF1和Bax的阳性表达率分别为36.3%、54.5%、60%。P21WAF1、Bax在良性组的表达分别为21.4%、28.6%，而在潜在恶性组、恶性组明显增高。P27KIP1在良性组的表达率为64.3%，明显高于潜在恶性组、恶性组(21.4%、29.6%)。P27KIP1、P21WAF1和Bax三者在潜在恶性组、恶性组的表达与良性组比较差异有统计学意义，而潜在恶性组与恶性组之间差异无统计学意义。P27KIP1、P21WAF1和Bax的表达与胃肠道间质瘤患者的性别、年龄、部位、肿瘤大小、有无坏死、组织学分型无关，而与其恶性潜能分级相关。结论 P27KIP1的低表达、P21WAF1和Bax的高表达与胃肠道间质瘤临床恶性潜能密切相关。
目的：探討P27KIP1、P21WAF1和Bax在胃腸道間質瘤中的錶達及其與臨床生物學行為的相關性。方法採用免疫組化法檢測P27KIP1、P21WAF1和Bax在胃腸道間質瘤中的暘性錶達情況，併在良性組、潛在噁性組、噁性病例組之間進行比較。結果55例胃腸道間質瘤中，P27KIP1、P21WAF1和Bax的暘性錶達率分彆為36.3%、54.5%、60%。P21WAF1、Bax在良性組的錶達分彆為21.4%、28.6%，而在潛在噁性組、噁性組明顯增高。P27KIP1在良性組的錶達率為64.3%，明顯高于潛在噁性組、噁性組(21.4%、29.6%)。P27KIP1、P21WAF1和Bax三者在潛在噁性組、噁性組的錶達與良性組比較差異有統計學意義，而潛在噁性組與噁性組之間差異無統計學意義。P27KIP1、P21WAF1和Bax的錶達與胃腸道間質瘤患者的性彆、年齡、部位、腫瘤大小、有無壞死、組織學分型無關，而與其噁性潛能分級相關。結論 P27KIP1的低錶達、P21WAF1和Bax的高錶達與胃腸道間質瘤臨床噁性潛能密切相關。
목적：탐토P27KIP1、P21WAF1화Bax재위장도간질류중적표체급기여림상생물학행위적상관성。방법채용면역조화법검측P27KIP1、P21WAF1화Bax재위장도간질류중적양성표체정황，병재량성조、잠재악성조、악성병례조지간진행비교。결과55례위장도간질류중，P27KIP1、P21WAF1화Bax적양성표체솔분별위36.3%、54.5%、60%。P21WAF1、Bax재량성조적표체분별위21.4%、28.6%，이재잠재악성조、악성조명현증고。P27KIP1재량성조적표체솔위64.3%，명현고우잠재악성조、악성조(21.4%、29.6%)。P27KIP1、P21WAF1화Bax삼자재잠재악성조、악성조적표체여량성조비교차이유통계학의의，이잠재악성조여악성조지간차이무통계학의의。P27KIP1、P21WAF1화Bax적표체여위장도간질류환자적성별、년령、부위、종류대소、유무배사、조직학분형무관，이여기악성잠능분급상관。결론 P27KIP1적저표체、P21WAF1화Bax적고표체여위장도간질류림상악성잠능밀절상관。
Objective To investigate the correlation between biological behavior and expression of P27KIP1, P21WAF1 and Bax in gastrointestinal stromal tumors. Methods Immunohistochemical method was used to detect P27KIP1, P21WAF1 and Bax expression in 55 cases of GIST, which were compared among benign GIST, potential malig-nant GIST, and malignant GIST. Results In 55 cases of GIST, the positive expression rates of P27KIP1, P21WAF1 and Bax were 36.3%, 54.5%, 60%. The expression rate of P21WAF1 and Bax were 21.4%, 28.6% in benign GIST, which were significantly increased in potential malignant GIST and malignant GIST. The expression rate of P27KIP1 in benign GIST (64.3%) was significantly higher than that in potential malignant GIST (21.4%) and malignant GIST (29.6%). The expression rate of P27KIP1, P21WAF1 and Bax showed statistically significant difference between benign GIST and po-tential malignant GIST, malignant GIST, but showed no statistically significant difference between potential malignant GIST and malignant GIST. The expressions of P27KIP1, P21WAF1 and Bax showed no correlation with age, sex, location, size, necrosis and histological scheme, but they were related with the malignant progression. Conclusion The low ex-pression of P27KIP1, the high expression of P21WAF1 and Bax are closely related to clinical malignant potential of GIST.
