CAJ | 학술논문

目的：了解本地区人群血清尿酸(UA)水平及其相关危险因素。方法收集15632例体检人群的血尿酸(UA)、尿素(Urea)、肌酐(Crea)、空腹血糖(FPG)、总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)等8项生化指标，并分析UA水平和高尿酸血症(HUA)的危险因素。结果体检人群HUA的患病率为36.24%(5665/15632)，男性HUA患病率是女性的2.2倍。UA水平、HUA患病率在不同性别、年龄之间差异有统计学意义(P<0.05)。UA水平、HUA患病率随年龄增长呈“J”形曲线变化。Pearson相关分析结果显示，UA水平与年龄、FPG、TC、TG、LDL-C、Urea和Crea呈正相关(P均<0.01)，与HDL-C、性别呈负相关(P均<0.01)；多元线性回归分析结果显示，FPG、HDL-C和女性是HUA的保护因素，TG、LDL-C、Urea和Crea是HUA水平的危险因素；多因素Logistic回归分析结果显示，FPG、TC和HDL-C是HUA的保护因素，性别、TG、LDL-C、Urea和Crea是HUA的危险因素。结论总体检人群UA水平随年龄增长呈“J”形曲线变化。TC、TG、LDL-C、Urea和Crea是HUA的危险因素，而HDL-C、女性是HUA的保护因素。
목적：료해본지구인군혈청뇨산(UA)수평급기상관위험인소。방법수집15632례체검인군적혈뇨산(UA)、뇨소(Urea)、기항(Crea)、공복혈당(FPG)、총담고순(TC)、감유삼지(TG)、고밀도지단백담고순(HDL-C)、저밀도지단백담고순(LDL-C)등8항생화지표，병분석UA수평화고뇨산혈증(HUA)적위험인소。결과체검인군HUA적환병솔위36.24%(5665/15632)，남성HUA환병솔시녀성적2.2배。UA수평、HUA환병솔재불동성별、년령지간차이유통계학의의(P<0.05)。UA수평、HUA환병솔수년령증장정“J”형곡선변화。Pearson상관분석결과현시，UA수평여년령、FPG、TC、TG、LDL-C、Urea화Crea정정상관(P균<0.01)，여HDL-C、성별정부상관(P균<0.01)；다원선성회귀분석결과현시，FPG、HDL-C화녀성시HUA적보호인소，TG、LDL-C、Urea화Crea시HUA수평적위험인소；다인소Logistic회귀분석결과현시，FPG、TC화HDL-C시HUA적보호인소，성별、TG、LDL-C、Urea화Crea시HUA적위험인소。결론총체검인군UA수평수년령증장정“J”형곡선변화。TC、TG、LDL-C、Urea화Crea시HUA적위험인소，이HDL-C、녀성시HUA적보호인소。
Objective To explore the serum uric acid (UA) level distribution and relevant risk factors in gener-al population of Panyu district. Methods Eighty biochemical indicators including UA, urea (Urea), creatinine (Crea), fasting plasma glucose (FPG), total cholesterol (TC), triglyceride (TG), high density lipoprotein (HDL-C), low density li-poprotein (LDL-C) were collected from 15 632 local residents. And risk factors of UA level and hyperuricemia (HUA) prevalence rate were analysed. Results The HUA prevalence rate was 36.24%(5 665/15 632), and that HUA preva-lence rate of males was 2.2 times than that of females. The differences of UA level and HUA prevalence rate between genders and ages were statistically significant (P<0.05). The UA level and HUA prevalence rate showed a“J”curve rela-tionship with aging. The Pearson correlation analysis showed that UA level was positively correlated with age, FPG, TC, TG, LDL-C, Urea and Crea, while negatively correlated with HDL-C and female gender. Multiple linear regression anal-ysis showed that TG, LDL-C, Urea and Crea were risk factors, while FPG, HDL-C and female gender were the protec-tive factors of HUA;And multiple Logistic regression analysis showed that gender, TG, LDL-C, Urea and Crea were risk factors, while FPG, TC and HDL-C were the protective factors of HUA. Conclusion The Serum UA level in gen-eral population showed a“J”curve relationship with aging. TC, TG, LDL-C, Urea and Crea are risk factors of HUA, while female gender and HDL-C are the protective factors.